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Published Online: 19 May 2021

First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder

Fabrice Duval, M.D., Alexis Erb, M.D., Marie‐Claude Mokrani, Ph.D., Thomas Weiss, M.D., and Roberta Carcangiu, M.D.Authors Info & Affiliations

Publication: Psychiatric Research and Clinical Practice

Volume 3, Number 4

https://doi.org/10.1176/appi.prcp.20210010

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Abstract

Objective

We examined whether the anti‐saccade task (AST) performance after the first methylphenidate (MPH) dose could be associated with subsequent clinical outcome in adults with attention‐deficit/hyperactivity disorder (ADHD).

Methods

Ninety‐seven drug‐naive DSM‐5 ADHD adults participated in this study. The AST parameters were measured at baseline, after the first MPH‐dose (10 mg orally), and 6 months after chronic MPH treatment. Results were compared with those of 50 healthy control (HC) subjects.

Results

At baseline, ADHDs showed longer saccadic reaction times and more direction errors than HCs (both p < 0.00001). Acute and chronic MPH administration resulted in normalization of the AST performances. Multivariate regression analysis after adjusting for age, sex, weight, and severity of symptoms at baseline, revealed that a low percentage of direction errors after the first MPH‐dose (i.e., ≤10%) could predict remission at month 6 (OR: 5.84; 95% CI: 2.00–17.11; p = 0.001).

Conclusions

Our findings indicate that: (1) impairments of motor planning and response inhibition in adults with ADHD are improved with MPH, and (2) a low direction error percentage after the first MPH‐dose may be an independent predictor of remission.

ClinicalTrials.gov identifier: NCT03411434

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Information & Authors

Information

Published In

Go to Psychiatric Research and Clinical Practice

Psychiatric Research and Clinical Practice

Volume 3 • Number 4 • Winter 2021

Pages: 146 - 152

History

Received: 23 February 2021

Revision received: 27 April 2021

Accepted: 30 April 2021

Published online: 19 May 2021

Published in print: Winter 2021

Authors

Details

Fabrice Duval, M.D.

Pôle 8/9 Psychiatry, APF2R, Centre Hospitalier, Rouffach, France (F. Duval, A. Erb, M. Mokrani, T. Weiss, R. Carcangiu)

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Alexis Erb, M.D.

Pôle 8/9 Psychiatry, APF2R, Centre Hospitalier, Rouffach, France (F. Duval, A. Erb, M. Mokrani, T. Weiss, R. Carcangiu)

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Marie‐Claude Mokrani, Ph.D.

Pôle 8/9 Psychiatry, APF2R, Centre Hospitalier, Rouffach, France (F. Duval, A. Erb, M. Mokrani, T. Weiss, R. Carcangiu)

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Thomas Weiss, M.D.

Pôle 8/9 Psychiatry, APF2R, Centre Hospitalier, Rouffach, France (F. Duval, A. Erb, M. Mokrani, T. Weiss, R. Carcangiu)

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Roberta Carcangiu, M.D.

Pôle 8/9 Psychiatry, APF2R, Centre Hospitalier, Rouffach, France (F. Duval, A. Erb, M. Mokrani, T. Weiss, R. Carcangiu)

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Notes

Correspondence
Dr. Duval ([email protected])

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