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Abstract

Objective

Individuals with a history of suicidality may be especially vulnerable to the adverse impact of COVID‐related stressors, but this vulnerability has not been demonstrated. This study examined the longitudinal effects of suicidality history (ideation only or attempt vs. none) and interactions with COVID‐related stressors (e.g., work interruptions, childcare challenges, and financial stress) on anxiety symptoms, depressive symptoms, and problematic drinking.

Methods

Longitudinal data from 517 participants were drawn from the National Institute on Alcohol Abuse and Alcoholism Natural History Protocol and COVID‐19 Pandemic Impact on Alcohol Study. Lifetime history of suicidality was assessed using the clinician administered Columbia‐Suicide Severity Rating Scale. Multiple regressions tested the interaction between suicidality history and COVID‐related stressors on clinical outcomes.

Results

Compared to individuals without any history of suicidality (79.9%; n = 413), individuals with a history of suicide ideation only (14.5%; n = 75) and suicide attempt (5.6%; n = 29) had higher anxiety symptoms, depressive symptoms, and problematic drinking during the pandemic. Significant interaction effects showed the associations between COVID‐related stressors and mental disorder symptoms were stronger among individuals with suicide attempt history than individuals without suicidality history.

Conclusions

History of suicide attempt in combination with high COVID‐related stressors put individuals at the greatest risk for pandemic mental disorder symptoms. Individuals with suicide attempt history may have lower coping resources to handle COVID‐related stressors. Suicide risk assessment and intervention to increase cognitive flexibility and emotional regulation skills may help these individuals manage emotional distress experienced during the COVID‐19 pandemic and beyond.

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Supplementary Material

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Tables S1–S3

Information & Authors

Information

Published In

Go to Psychiatric Research and Clinical Practice
Psychiatric Research and Clinical Practice
Pages: 78 - 86

History

Received: 14 November 2023
Revision received: 16 January 2024
Accepted: 24 January 2024
Published online: 2 May 2024
Published in print: Autumn (Fall) 2024

Authors

Details

National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)
Matthew F. Thompson, M.S.
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)
Laura A. Novak, M.S., M.P.S.
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)
Bethany L. Stangl, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)
Melanie L. Schwandt, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)
Vijay A. Ramchandani, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)
Nancy Diazgranados, M.D., M.S.
National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA (J. W. Luk, M. F. Thompson, L. A. Novak, M. L. Schwandt, D. Goldman, N. Diazgranados); Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, Maryland, USA (M. F. Thompson, L. A. Novak); Human Psychopharmacology Laboratory, NIAAA, Bethesda, Maryland, USA (B. L. Stangl, V. A. Ramchandani); Laboratory of Neurogenetics, NIAAA, Rockville, Maryland, USA (D. Goldman)

Notes

Send correspondence to Dr. Luk ([email protected])

Author Contributions

Vijay A. Ramchandani and Nancy Diazgranados have equally contributed as senior authors.

Author Contributions

This study was supported by NIAAA Division of Intramural Clinical and Biological Research (Z1A AA000130, Z1A AA000466) and a NIAID Intramural Targeted Anti‐COVID (ITAC) Award.

Author Contributions

The authors would like to thank the NIAAA clinicians, staff, and post‐baccalaureate research assistants who helped collect or manage this data, as well as other members of the NIAAA Human Psychopharmacology Laboratory, the Office of the Clinical Director, the Clinical NeuroImaging Research Core, and the Section on Sensory Science and Metabolism.

Author Contributions

The authors do not have any conflicts of interest to disclose.

Funding Information

NIAID
NIAAA Division of Intramural Clinical and Biological Research: AA000130, AA000466

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