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Abstract

Objective:

The study examined changes in French general practitioners’ (GPs) antipsychotic preferences between 2003 and 2010, a period when evidence challenging the superiority and safety of second-generation antipsychotics was introduced.

Methods:

Data from the IMS Health Disease Analyzer database for a cohort of 347 GPs (with 12 or more antipsychotic prescriptions in 2003 and in 2010) were used. For each year and GP, preferred antipsychotic was defined as the drug most frequently prescribed at the patient level. Trends in mean number of prescriptions, preferred drug, and changes in preferred antipsychotic class were documented.

Results:

The mean annual number of antipsychotic prescriptions increased over the period (p<.001). The percentage of GPs who preferred a second-generation antipsychotic tripled, from 16% in 2003 to 50% in 2010. In 2010, 42% of GPs who preferred first-generation antipsychotics in 2003 had switched their preference to second-generation antipsychotics.

Conclusions:

GPs’ preferences for antipsychotics changed dramatically between 2003 and 2010.

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Information

Published In

Go to Psychiatric Services
Go to Psychiatric Services

Cover: Breakfast in the Garden, by Frederick Carl Frieseke, circa 1911. Oil on canvas, 26 x 325/16 inches. Daniel J. Terra Collection, 1987.21. Terra Foundation for American Art, Chicago/Art Resource, New York City.

Psychiatric Services
Pages: 434 - 437
PubMed: 25588416

History

Received: 17 January 2014
Revision received: 24 June 2014
Accepted: 21 August 2014
Published online: 15 January 2015
Published in print: April 01, 2015

Authors

Details

Adeline Gallini, Pharm.D., Ph.D.
Except for Dr. Donohue, the authors are with the Department of Epidemiology, University of Toulouse, Toulouse, France, and with INSERM UMR 1027, Toulouse (e-mail: [email protected]). Dr. Donohue is with the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Virginie Gardette, M.D., Ph.D.
Except for Dr. Donohue, the authors are with the Department of Epidemiology, University of Toulouse, Toulouse, France, and with INSERM UMR 1027, Toulouse (e-mail: [email protected]). Dr. Donohue is with the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Naïma Oumouhou, M.Sc.
Except for Dr. Donohue, the authors are with the Department of Epidemiology, University of Toulouse, Toulouse, France, and with INSERM UMR 1027, Toulouse (e-mail: [email protected]). Dr. Donohue is with the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Sandrine Andrieu, M.D., Ph.D.
Except for Dr. Donohue, the authors are with the Department of Epidemiology, University of Toulouse, Toulouse, France, and with INSERM UMR 1027, Toulouse (e-mail: [email protected]). Dr. Donohue is with the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Julie M. Donohue, Ph.D.
Except for Dr. Donohue, the authors are with the Department of Epidemiology, University of Toulouse, Toulouse, France, and with INSERM UMR 1027, Toulouse (e-mail: [email protected]). Dr. Donohue is with the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.

Competing Interests

Dr. Andrieu has received consulting fees, payment for lectures, or institution grant support from Beaufour Ipsen Pharma SAS, Chiesi, Elan, Eli Lilly and Company, Esai Inc., Exhonit, Janssen, Lundbeck Inc., Nestle S.A., Novartis, Pfizer, Pierre Fabre Laboratories, Roche, Sanofi, and Servier. The other authors report no financial relationships with commercial interests.

Funding Information

This research was supported by an unconditional grant from the Direction de la Recherche, des Études, de l’Évaluation et des Statistiques (DREES), Ministry for Health, France. Access to data from IMS Health Disease Analyzer was authorized under a contract with DREES within France’s Ministry for Health. The funding organization had no role in the design or conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.

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