Skip to main content
Full access
Brief Reports
Published Online: 1 June 2015

Readiness to Implement an Evidence-Based Psychotherapy: Perspectives of Community Mental Health Clinicians and Administrators

Abstract

Objective:

Using evidence-based psychotherapies in community mental health clinics could significantly improve patient functioning. This study explored perceived facilitators and barriers related to implementing interpersonal and social rhythm therapy (IPSRT), an evidence-based psychotherapy for bipolar disorder.

Methods:

The authors conducted 30-minute semistructured interviews with clinic administrators, supervisors, and clinicians from five community mental health clinics focusing on anticipated barriers and facilitators related to implementing IPSRT.

Results:

Seventeen participants (four administrators, three supervisors, and ten clinicians) completed the interviews. Important barriers to effective implementation included frequent client no-shows, difficulties transitioning from training to practice, and time constraints. Facilitators included support from supervisors and other clinicians, decreased productivity requirements or compensation for time spent while learning IPSRT, and reference materials.

Conclusions:

Administrators and clinicians expressed similar beliefs about facilitators and barriers related to implementing IPSRT. The challenge of high no-show rates was not identified as a barrier in previous research.
Investigators have identified a range of influential factors supporting effective implementation of evidence-based practices in real-world mental health outpatient clinics. These factors include clinicians’ attitudes toward evidence-based practices in general; organizational culture, climate, and resources; clinician professional background; training approach and intention to use the evidence-based practice; and available support from peers trained in the same approach (14). Some factors, such as attitudes toward evidence-based practices and the intention to use them, are within the purview of the clinician; others, such as resources to support the evidence-based practice and choice of the type of training and nature of the implementation support, are decisions made by administrators. As a further challenge, the incentives of clinicians and administrators to implement evidence-based practices may not always align. For example, clinicians may seek support to attend training in an evidence-based practice, but administrators may be concerned that clinicians with newly acquired skills would leave the clinic (5).
Few studies have examined the implementation of psychotherapies delivered primarily in outpatient clinics. Clearly, a greater understanding of how to implement evidence-based psychotherapies is needed, especially studies that consider both administrator and clinician perspectives. We are unaware of any studies that have examined implementation of evidence-based psychotherapies across a broad range of clinic staff. To address this gap, we asked community mental health personnel to anticipate barriers to and facilitators of implementing an evidence-based psychotherapy. The personnel were interviewed prior to their participation in a study of alternative approaches to implementation of interpersonal and social rhythm therapy (IPSRT), an evidence-based psychotherapy for treating individuals at all levels of acuity and in any phase of bipolar disorder.

Methods

We selected 17 participants (four administrators, three supervisors, and ten clinicians) from five community mental health clinics that did not routinely implement structured evidence-based psychotherapies. The clinics were participating in a study examining the feasibility and acceptability of alternative approaches to supporting implementation of IPSRT. We invited all clinic administrators and supervisors to be interviewed; we randomly selected clinicians to participate from among all clinicians at the clinics who had experience treating patients with bipolar disorder and who would also be participating in the subsequent study. All selected individuals consented to participate in this qualitative investigation.
Approximately one month before IPSRT training began, we conducted 30-minute semistructured interviews with study participants regarding the clinic’s readiness to implement IPSRT. Participants were primarily women (N=14, 82%;), and the majority (N=10; 59%) had been in their current clinic positions for less than five years. Two participants (12%) had been in their current position for five to ten years, two for 11 to 20 years (12%), and three (18%) for 21 to 30 years.
Interviews were audio recorded and transcribed, followed an interview guide, and focused on anticipated facilitators and barriers in implementing IPSRT in an outpatient clinic. A codebook was developed on the basis of an iterative reading of the transcripts. Once coders reached thematic consensus, a finalized codebook was created that contained both a question-specific coding approach and global qualitative themes that emerged from the text. The themes were then applied by two experienced analysts, who independently identified themes generated from responses or that emerged through the global thematic analysis. Coding disagreements were adjudicated through discussion. The University of Pittsburgh and RAND Institutional Review Boards approved the study.

Results

Below we describe the key themes that emerged from the interviews regarding both perceived barriers to and perceived facilitators of implementing IPSRT, provide illustrative quotations, and indicate whether the theme was more common among a specific type of participant.
The major anticipated barriers to implementing IPSRT fell into three main categories: logistical challenges to engaging clients, challenges in the transition from training to practice, and time constraints.
The anticipated barriers cited most commonly were logistical challenges to engaging clients. Administrators were substantially more likely than clinicians to express this concern. Interviewees anticipated being unable to engage clients in IPSRT as intended because they felt IPSRT would require regular and routine visits. One clinician related, “We have about a . . . 63% show rate for clients, so I can really get started and into something and then, for whatever reason, Jane Doe stops showing up for her appointments.” A supervisor at the same clinic discussed frequent client no-shows, explaining that mental disorders and limited financial and social resources challenge clients’ ability to adhere to recommended treatment. According to the supervisor, “Attendance is not always stellar. . . . A lot of it has to do with the severity of their illnesses, with their socioeconomic situation, with their ability to acquire transportation.” At a different clinic, an administrator described as a potential barrier the detailed personal tracking required by IPSRT, considering clients’ resistance to change. “It [tracking of social rhythms] is a change for some of the individuals . . . coming in for services,” according to the administrator. “What they may be used to and what they may be asked to track, to look at, things like that. And that’s always a barrier—getting individuals to [accept] change.”
Both clinicians and administrators commonly expressed concern about their ability to apply newly acquired knowledge of IPSRT to their clinical practice. Concerns ranged from the therapy “getting lost” in busy daily clinical activities to worries that it would not be implemented smoothly because fellow clinicians were reluctant to adopt new treatment approaches. Participants often lacked confidence that they would learn enough about IPSRT to use it appropriately. One said, “The biggest barrier is learning it and then sitting down and practicing it with clients. I think that there’s always that step in between. You know, it’s fine to say ‘Yes, I’m trained, I got some training in it,’ but I’m not sure how to use it well enough to use it with clients.” Some participants also expressed concern that changing treatment protocols could be difficult, either for themselves or for others. For example, one said, “There’s at least one [clinician] in the training group [who isn’t open to trying new things]. It’s not so much about trying new ideas; it’s just change in general.”
Likewise, some supervisors worried about supporting clinicians in implementing IPSRT and making the therapy a regular part of the clinic’s practice. According to one supervisor, “After the . . . training it’s still a little fuzzy on how we will get support if we need it. . . . We can support our staff and do clinical supervision from this model’s perspective. I think we’ll be able to learn this model pretty quickly, and probably be able to do clinical supervision. . . . But that could be a barrier if we [supervisors] don’t have access to ongoing support ourselves . . . just keeping it alive and making sure that folks are using it. And, going forward, as we have some staff turnover . . . how would we get new people up to speed?”
Having insufficient time to master and implement IPSRT was a common theme among both administrators and clinicians, given competing demands such as routine clinical activities and transitioning to electronic health records. As one supervisor noted, “Time is a factor. We’re all under the gun for productivity, to return phone calls, trying to do consults with the doctors . . . being pulled in different ways. It’s going to take definitely time to do [IPSRT], and time is always an issue here. . . . I could probably come to work for a whole week and not see a client and still have plenty to do.” An additional concern was how contracted clinicians, who are paid only for providing clinical services, would be compensated for learning and practicing IPSRT.
The most commonly identified facilitator of successful implementation was support at the clinic level in the form of supervision specific to IPSRT or group discussions of and consultations on use of IPSRT. Continued support from clinic staff and other clinicians was also viewed as a necessary, and potentially critical, follow-up to training and handouts, but it was mentioned more commonly by administrators and supervisors than by clinicians. One clinician observed, “But [in addition to the training] . . . I’m also a really big fan of having handouts for a quick referral back, too. . . . I [also] like the idea of having . . . booster sessions as far as homing in on those skills, so we could use . . . just kind of problem-solving groups where people can talk about areas that they’ve had trouble with. I think that they’re helpful in learning a new method.” Some participants envisioned support specific to IPSRT, and others imagined incorporating support into already existing clinical supervision. “[Clinicians] have weekly individual therapy and also have weekly supervision in terms of groups,” said one clinical supervisor. “We also do a lot of peer support. So if we know this is going to be a focus for individuals who suffer from bipolar [disorder], we can continue to encourage one another to keep using this . . . peer support, along with the team supervision.”
Comparable numbers of administrators or supervisors and clinicians felt that during the initial implementation phase, IPSRT use would be enhanced by decreasing productivity requirements or paying for time spent studying the new approach. Reimbursement for time spent learning IPSRT was particularly salient in clinics with a majority of contract clinicians. In those clinics, the need to spend unreimbursed time learning IPSRT or consulting with others was viewed as a potential implementation barrier. Recognizing reimbursement as a critically important issue, all clinics planned to compensate clinicians for training time, but none had yet developed plans to decrease productivity requirements or provide payment for posttraining activities.
Both administrators and clinicians often stressed the importance of gaining sufficient understanding of IPSRT during training, with special focus on strategies to facilitate treatment use and usability. “Getting a good basic understanding of it in initial training,” as one administrator explained, was an essential foundation. Several participants also discussed specific information about IPSRT that would be helpful, such as its most common benefits for patients and its similarities to and differences from other therapies used in the clinic. Obtaining practical knowledge of how to conduct IPSRT was also commonly mentioned. As one clinician related, “As much as [the training] can be, ‘What’s going to be the benefit and how do I use this with a client sitting in front of me?’ and not, ‘Here’s what the data say, here’s all the good things it can do.’ But to actually say to people, ‘This is how you use this, this is how you facilitate this technique. This is how you use some of these things.’ A lot of things talk about the research benefits, but they don’t actually tell clinicians how to use them.”
Numerous participants also discussed a need for readily accessible, highly usable reference materials, both for themselves and clients, to refresh or supplement what participants had learned in training and to help explain IPSRT to patients, monitor progress, or both.

Discussion

We found that despite strong and supportive leadership, staff anticipated a number of potential challenges to successfully implementing IPSRT. Many of the factors identified are consistent with prior implementation studies; however, we are unaware of prior studies identifying concerns about high rates of client no-shows or studies reporting that overall, clinicians, administrators, and supervisors expressed convergent beliefs about barriers to and facilitators in implementing an evidence-based therapy.
Adequate training and knowledge related to the intervention, competing time demands, and sufficient peer and supervisor support have all been identified as factors influencing effective implementation (6,7). Decreased productivity requirements and adequate reimbursement were also commonly cited issues (5) because clinicians are often less productive while mastering a new intervention. Administrators and supervisors were aware of this challenge. However, none of the clinics in our study had made plans to address the issue.
Community mental health clinics commonly operate on very thin margins, often reimbursed at very low rates for each service unit provided. As a result, high service volume is a priority for both the organization and for individual clinicians. Lowering productivity requirements to allow clinicians to master new interventions is challenging. Payers and community mental health organizations will need to address this issue thoughtfully and directly if they wish to enhance the capacity of the community mental health workforce to implement effective mental health therapies.
Concern about how client attendance rates could affect adherence to IPSRT and, implicitly, therapists’ ability to master the approach was also cited as a potential implementation barrier. Although the implementation literature identifies a good fit between intervention and setting as an important factor for successful intervention implementation (8), we are unaware of studies explicitly identifying inconsistent client attendance as a barrier to implementing evidence-based psychotherapies. No-show rates are often high in community mental health outpatient settings, in the range of 35%−50% (9). Further research is needed to better understand how inconsistent client attendance may affect the implementation and effectiveness of therapies in community outpatient clinics. However, given the strong concern about the issue expressed by study participants, intervention developers may consider incorporating tools and strategies to address this challenge.
Our findings must be viewed within the context of the study limitations. We interviewed 17 individuals from five community mental health centers in a large mid-Atlantic state, centers where organizational leadership had committed to implementing IPSRT as part of a federally funded implementation study. Additional issues may have arisen if the interviewees had been from organizations without such leadership commitment, had more or less experience implementing evidence-based psychotherapies, or worked in states with a less robust specialty mental health system. Although new themes related to IPSRT implementation ceased to emerge among the last participants interviewed, other themes may have arisen had there been more interviewees, interviewees from other organizations, or interviewees from other geographic regions. Finally, this study was part of a larger study examining alternative approaches to feasibly and efficiently implement IPSRT in community mental health settings. The goal of this study was to better understand the implementation of an evidence-based therapy within common community mental health setting constraints rather than support implementation during the study period. Findings from subsequent study stages will help community mental health providers make informed choices regarding how best to implement evidence-based psychotherapies and other interventions.

Conclusions

Despite these limitations, our findings contribute to the evolving literature regarding implementation of evidence-based psychotherapies in community settings. These therapies have the potential to extend the reach and improve the quality of care to many individuals with mental health needs, but “a sound program will not produce the desired results if it is implemented poorly” (10). Ensuring effective implementation is complicated, requiring a thorough understanding of facilitators and barriers. Our finding that clinicians and administrators often share the same concerns about implementation should facilitate the development of materials and approaches designed to address them. However, the impact of high no-show rates on treatment adherence when introducing evidence-based psychotherapies into community settings constitutes a newly identified concern. Implementation planning efforts can use preimplementation periods to identify barriers that were previously unidentified or that are potentially unique to the participating delivery system (11) as well as to engage a broad range of delivery system stakeholders in discussions about the potential benefits of effective intervention implementation.
However, our findings also demonstrate that awareness of important implementation challenges does not always precipitate actions to address them. Evidence-based practices deserve evidence-based implementation (12). Approaches such as learning collaboratives are increasingly used to support mental health intervention implementation in community settings (13), but further research is needed to understand whether learning collaboratives (13,14) and other implementation interventions (15) change behaviors in a way that supports effective and sustainable evidence-based psychotherapies.

References

1.
Jensen-Doss A, Cusack KJ, de Arellano MA: Workshop-based training in trauma-focused CBT: an in-depth analysis of impact on provider practices. Community Mental Health Journal 44:227–244, 2008
2.
Aarons GA: Transformational and transactional leadership: association with attitudes toward evidence-based practice. Psychiatric Services 57:1162–1169, 2006
3.
Aarons GA, Sawitzky AC: Organizational climate partially mediates the effect of culture on work attitudes and staff turnover in mental health services. Administration and Policy in Mental Health and Mental Health Services Research 33:289–301, 2006
4.
Beidas RS, Kendall PC: Training therapists in evidence-based practice: a critical review of studies from a systems-contextual perspective. Clinical Psychologist 17:1–30, 2010
5.
Herschell AD, Kogan JN, Celedonia KL, et al: Understanding community mental health administrators’ perspectives on dialectical behavior therapy implementation. Psychiatric Services 60:989–992, 2009
6.
McHugh RK, Barlow DH: The dissemination and implementation of evidence-based psychological treatments: a review of current efforts. American Psychologist 65:73–84, 2010
7.
Marshall T, Rapp CA, Becker DR, et al: Key factors for implementing supported employment. Psychiatric Services 59:886–892, 2008
8.
Greenhalgh T, Robert G, Macfarlane F, et al: Diffusion of innovations in service organizations: systematic review and recommendations. Milbank Quarterly 82:581–629, 2004
9.
Gallucci G, Swartz W, Hackerman F: Impact of the wait for an initial appointment on the rate of kept appointments at a mental health center. Psychiatric Services 56:344–346, 2005
10.
Mihalic SF, Irwin K, Fagan A, et al: Successful Program Implementation: Lessons From Blueprints. Washington, DC, US Department of Justice, Office of Justice Programs, Office of Juvenile Justice and Delinquency Prevention, 2004
11.
Chamberlain P, Brown CH, Saldana L: Observational measure of implementation progress in community based settings: the Stages of Implementation Completion (SIC). Implementation Science 6:116, 2011
12.
Herschell AD, Kolko DJ, Baumann BL, et al: The role of therapist training in the implementation of psychosocial treatments: a review and critique with recommendations. Clinical Psychology Review 30:448–466, 2010
13.
Nadeem E, Olin SS, Hill LC, et al: A literature review of learning collaboratives in mental health care: used but untested. Psychiatric Services 65:1088–1099, 2014
14.
Young PC, Glade GB, Stoddard GJ, et al: Evaluation of a learning collaborative to improve the delivery of preventive services by pediatric practices. Pediatrics 117:1469–1476, 2006
15.
Glisson C, Schoenwald SK, Hemmelgarn A, et al: Randomized trial of MST and ARC in a two-level evidence-based treatment implementation strategy. Journal of Consulting and Clinical Psychology 78:537–550, 2010

Information & Authors

Information

Published In

Go to Psychiatric Services
Go to Psychiatric Services

Cover: Avenue of Oaks at Litchfield Plantation, by Elizabeth O'Neill Verner, circa 1940. Oil on board. The Morris Museum of Art, museum purchase; 1993.003. © Estate of Elizabeth O'Neill Verner/licensed by VAGA, New York City.

Psychiatric Services
Pages: 1109 - 1112
PubMed: 26030318

History

Received: 19 September 2014
Revision received: 23 December 2014
Accepted: 22 January 2015
Published online: 1 June 2015
Published in print: October 01, 2015

Authors

Details

Megan Hamm, Ph.D.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).
Kelly Williams, B.S.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).
Cara Nikolajski, M.P.H.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).
Karen L. Celedonia, M.P.H.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).
Ellen Frank, Ph.D.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).
Holly A. Swartz, M.D.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).
Susan L. Zickmund, Ph.D.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).
Bradley D. Stein, M.D., Ph.D.
Dr. Hamm and Ms. Williams are with the Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Ms. Nikolajski is with the Center for High-Value Health Care, University of Pittsburgh Medical Center, Pittsburgh. Ms. Celedonia and Dr. Stein are with RAND Corporation, Pittsburgh. Dr. Stein is also with the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, where Dr. Frank and Dr. Swartz are affiliated. Dr. Zickmund is with the Center for Health Equity Research and Promotion, U.S. Department of Veterans Affairs Pittsburgh Healthcare System, Pittsburgh. Send correspondence to Dr. Stein (e-mail: [email protected]).

Funding Information

National Institute of Mental Health: R34MH091319
The National Institute of Mental Health of the National Institutes of Health (award R34MH091319) provided support for this study. The authors are indebted to Gina Boyd, M.L.I.S., for research assistance, the leadership of the community mental health organizations for their support, and the clinicians, supervisors, and administrators for their willingness to share their perspectives.Dr. Frank is a stockholder in, serves on the advisory board of, or has received an honorarium for a presentation to Psychiatric Assessments, Inc., Health Rhythms, Servier International, and Lundbeck. She receives royalties from Guilford Press for the interpersonal and social rhythm therapy manual. The other authors report no financial relationships with commercial interests.

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format
Citation style
Style
Copy to clipboard

View Options

View options

PDF/EPUB

View PDF/EPUB

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login
Purchase Options

Purchase this article to access the full text.

PPV Articles - Psychiatric Services

PPV Articles - Psychiatric Services

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Media

Figures

Other

Tables

Share

Share

Share article link

Share