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Published Online: 16 October 2019

Access to Direct-Acting Antiviral Treatment for Hepatitis C Virus Among Veterans With Serious Mental Illness

Letitia E. Travaglini, Ph.D. [email protected], Julie Kreyenbuhl, Pharm.D., Ph.D., Meagan Graydon, Ph.D., Clayton H. Brown, Ph.D., Richard Goldberg, Ph.D., Seth Himelhoch, M.D., M.P.H., Li Juan Fang, M.S., and Eric Slade, Ph.D.Authors Info & Affiliations
Publication: Psychiatric Services
Volume 71, Number 2
https://doi.org/10.1176/appi.ps.201900227
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Abstract

Objective:

This study examined whether serious mental illness is associated with initiating and with completing sofosbuvir-based treatment for hepatitis C virus (HCV) among veterans who started treatment after the Veterans Health Administration (VHA) received expanded funding for HCV care.

Methods:

Administrative health care data from fiscal years 2016–2017 revealed 4,288 treatment-naïve patients with HCV, of whom 1,311 had initiated sofosbuvir-based treatment. Dependent variables were initiation and completion of ≥8 weeks of sofosbuvir treatment. Associations with serious mental illness were estimated with adjusted odds ratios from multivariable logistic regression analyses.

Results:

No statistically significant differences were found in the proportion of veterans with and veterans without serious mental illness who initiated (p=0.628) or completed ≥8 weeks (p=0.301) of sofosbuvir treatment.

Conclusions:

Veterans with and without serious mental illness initiated and completed sofosbuvir treatment at similar rates. The VA should continue to provide equitable access to HCV treatments and support medication adherence.

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Information & Authors

Information

Published In

Go to Psychiatric Services
Go to Psychiatric Services
Psychiatric Services
Volume 71 • Number 2 • February 01, 2020
Pages: 192 - 195
PubMed: 31615365

History

Received: 3 May 2019
Revision received: 9 August 2019
Accepted: 21 August 2019
Published online: 16 October 2019
Published in print: February 01, 2020

Keywords

  1. Veterans issues
  2. Serious mental illness
  3. Hepatitis C
  4. Direct-acting antiviral treatment

Authors

Details

Letitia E. Travaglini, Ph.D. [email protected]
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Julie Kreyenbuhl, Pharm.D., Ph.D.
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Meagan Graydon, Ph.D.
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Clayton H. Brown, Ph.D.
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Richard Goldberg, Ph.D.
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Seth Himelhoch, M.D., M.P.H.
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Li Juan Fang, M.S.
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Eric Slade, Ph.D.
Veterans Affairs (VA) Capitol Healthcare Network (VISN 5) Mental Illness Research, Education and Clinical Center (MIRECC), Baltimore (Travaglini, Kreyenbuhl, Brown, Goldberg); Division of Psychiatric Services Research, Department of Psychiatry (Kreyenbuhl, Goldberg, Fang, Slade), and Department of Epidemiology and Public Health (Brown), University of Maryland School of Medicine, Baltimore; VA Maryland Health Care System, Baltimore (Graydon); Department of Psychiatry, University of Kentucky College of Medicine, Lexington (Himelhoch); Johns Hopkins University School of Nursing, Baltimore (Slade).
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Notes

Send correspondence to Dr. Travaglini ([email protected]).

Funding Information

VISN 5 MIRECC Pilot Resource Fund

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