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Clinical and Research Report
Published Online: 1 May 1998

Neuroleptic Sensitivity to Clozapine in Dementia With Lewy Bodies

William J. Burke, M.D., Ronald F. Pfeiffer, M.D., and Rodney D. McComb, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 10, Number 2
https://doi.org/10.1176/jnp.10.2.227
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Abstract

Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because hallucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to neuroleptics with respect to developing extrapyramidal symptoms. The authors describe 2 patients with DLB who were intolerant of clozapine, showing not extrapyramidal side effects, but an increase in confusion and behavioral symptoms.

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 10 • Number 2 • May 1998
Pages: 227 - 229
PubMed: 9608415

History

Published online: 1 May 1998
Published in print: May 1998

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William J. Burke, M.D.
Received January 28, 1997; revised May 23, 1997; accepted May 30, 1997. From the Departments of Psychiatry, Neurology, and Pathology/Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. Address correspondence to Dr. Burke, 600 South 42nd Street, Omaha, NE 68198-5575; e-mail: [email protected]
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Ronald F. Pfeiffer, M.D.
Received January 28, 1997; revised May 23, 1997; accepted May 30, 1997. From the Departments of Psychiatry, Neurology, and Pathology/Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. Address correspondence to Dr. Burke, 600 South 42nd Street, Omaha, NE 68198-5575; e-mail: [email protected]
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Rodney D. McComb, M.D.
Received January 28, 1997; revised May 23, 1997; accepted May 30, 1997. From the Departments of Psychiatry, Neurology, and Pathology/Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. Address correspondence to Dr. Burke, 600 South 42nd Street, Omaha, NE 68198-5575; e-mail: [email protected]
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