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Published Online: 1 August 2004

A Pilot Study of Functional Magnetic Resonance Imaging Brain Correlates of Deception in Healthy Young Men

F. Andrew Kozel, M.D., Letty J. Revell, B.S., Jeffrey P. Lorberbaum, M.D., Ananda Shastri, Ph.D., Jon D. Elhai, Ph.D., Michael David Horner, Ph.D., Adam Smith, Ziad Nahas, M.D., Daryl E. Bohning, Ph.D., and Mark S. George, M.DAuthors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 16, Number 3
https://doi.org/10.1176/jnp.16.3.295
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Abstract

We hypothesized that specific brain regions would activate during deception, and these areas would correlate with changes in electrodermal activity (EDA). Eight men were asked to find money hidden under various objects. While functional MRI images were acquired and EDA was recorded, the subjects gave both truthful and deceptive answers regarding the money's location. The group analysis revealed significant activation during deception in the orbitofrontal cortex (OFCx) and anterior cingulate (AC), but individual results were not consistent. Individually and as a group, EDA correlated with blood flow changes in the OFCx and AC. Specific brain regions were activated during deception, but the present technique lacks good predictive power for individuals.

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 16 • Number 3 • August 2004
Pages: 295 - 305
PubMed: 15377736

History

Published online: 1 August 2004
Published in print: August 2004

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F. Andrew Kozel, M.D.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Letty J. Revell, B.S.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Jeffrey P. Lorberbaum, M.D.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Ananda Shastri, Ph.D.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Jon D. Elhai, Ph.D.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Michael David Horner, Ph.D.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Adam Smith
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Ziad Nahas, M.D.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Daryl E. Bohning, Ph.D.
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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Mark S. George, M.D
Received June 20, 2002; revised December 19 1002; accepted January 13, 2003. From the Center for Advanced Imaging Research, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Mental Health Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, Physics Department, Minnesota State University, Moorhead, Minnesota. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; [email protected] (E-mail).
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