Pisa Syndrome Resolved After Switching to Olanzapine

“Mr. A,” a 29-year-old man with a 3-year history of DSM-IV schizophrenia, had no history of head trauma or other neurological problems, and had no family history of dystonia or other movement disorders. In October 1999, he was admitted to the psychiatric unit for 9 months because of a severe psychotic exacerbation resulting in self-injuries of the tongue with scissors. A regimen of bromperidol, a maximum of 27 mg/day, and biperiden, 3 mg/day, was implemented with consequently good results. In the outpatient clinic, bromperidol was switched to risperidone at 4 mg/day, and then biperiden was discontinued.

In January 2001, 4 months after the initiation of risperidone, Mr. A was observed walking with a tilt toward the left. Physical examination showed tonic flexion of the trunk toward the left along with a slight backward axial rotation, classically referred to as Pisa syndrome. No evidence of other extrapyramidal symptoms was found. Secondary dystonias resulting from metabolic disorder, organic disorder, or infection were ruled out. The regimen of trihexyphenidyl was attempted for 4 weeks but no benefit was seen. A regimen of risperidone, 4 mg/day, was then reduced, step by step and cautiously, to 1 mg/day in 2 months. No improvement in Pisa syndrome was observed after 2-month observation with this dose. Because of the risk of psychotic relapse, risperidone, 1 mg/day, was successively switched to olanzapine, 5 mg/day, despite its discontinuation in August of 2001. Pisa syndrome gradually improved, and the symptoms disappeared within 2 months. Two years after olanzapine treatment, the patient was found to be in remission from the psychosis with no signs of Pisa syndrome.

The substitution to atypical antipsychotics, particularly clozapine, may provide alternatives for the treatment of patients with tardive dystonia. 2 Olanzapine, which has pharmacological similarities to clozapine, has been also suggested to be effective in the treatment of tardive dystonia. 3 For the treatment of Pisa syndrome, the usefulness of atypical antipsychotics has been mentioned only in a few case reports on clozapine 4 and amisulpride. 5 In this case, it remains unclear whether the clinical resolution of Pisa syndrome represents an antidystonic effect of olanzapine or simply a spontaneous remission of Pisa syndrome after the withdrawal of the offending drug, risperidone. Similar claims have been made for clozapine in the treatment of tardive dystonia. 4

Although the pathophysiological mechanism is still unclear, this case report demonstrates a possible usefulness of olanzapine as an antipsychotic mono-therapeutic strategy for Pisa syndrome, even if the syndrome is triggered by other atypical antipsychotics such as risperidone.