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Published Online: October 1947

TRIDIONE THERAPY : Special Aspects of Its Clinical Use

MEYER A. PERLSTEINAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 104, Number 4

https://doi.org/10.1176/ajp.104.4.247

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Abstract

1. A progress report of clinical observations in the therapeutic use of tridione on 136 cases of varied neurological manifestations, over a period of 2 years, is presented.

2. As previously reported, most spectacular benefits were obtained in cases of petit mal, where clinical improvement was immediate, associated with improvement in [SEE TABLE2 IN SOURCE PDF] the EEG pattern, and sustained often after cessation of the drug.

3. Tridione appears to be useful as an adjuvant drug in the treatment of grand mal seizures, though it does seem to aggravate some cases.

4. Both grand and petit mal of the idiopathic type were more responsive than those due to organic lesions.

5. Anticonvulsant action is indicated by its beneficial effects in cases of tetanus.

6. Tridione is of value in cerebral palsy, especially for reducing tension of the athetoid type.

7. Some forms of behavior disturbances are sedated by tridione.

8. Site of action for tridione appears to be the midbrain and (with some selectivity) the basal nuclei, an inference drawn from its failure to help patients with pyramidal lesions, while markedly benefiting extra-pyramidal lesions, with the exception of chorea, parkinsonism, and dystonia.

9. Toxic side-effects in the use of tridione, in our experience, were rare in children, were generally innocuous, and seemed readily reversible with cessation of the drug. More severe reactions were seen in adults.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 104 • Number 4 • October 1947

Pages: 247 - 253

PubMed: 18896724

History

Published in print: October 1947

Published online: 1 April 2006

Authors

Details

MEYER A. PERLSTEIN

The Children's Neurology Clinic of Cook County Hospital, Chicago, and St. John's Home and Hospital for Crippled Children, Springfield, Illinois.

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TRIDIONE THERAPY : Special Aspects of Its Clinical Use

Abstract

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