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Published Online: August 1954

METABOLIC STUDIES IN MONGOLISM : Serum Protein-Bound Iodine, Cholesterol, and Lipoprotein

ALEXANDER SIMON, CHARLES LUDWIG, JOHN W. GOFMAN , and G. HAMILTON CROOKAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 111, Number 2

https://doi.org/10.1176/ajp.111.2.139

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Abstract

1. In order to study thyroid and lipid function in mongolism, the levels of serum protein-bound iodine, cholesterol, and the fraction of S_f 12-20 molecules of lipoproteins were studied in a group of 74 mongoloid patients, and these were compared with the findings in normals and with a group of 18 cases diagnosed as "undifferentiated mental deficiency."

2. There was no significant difference in the serum protein-bound iodine levels between mongoloid children and "controls" of the same age.

3. Mentally retarded children, whether the diagnosis is mongolism or undifferentiated mental deficiency, have significantly higher serum cholesterol levels than normal children.

4. The most marked differences between mongoloids, normal, and control children occur in the level of large molecule lipoproteins of the S_f 12-20 class, the mongoloids being highest, the cases of undifferentiated mental deficiency intermediate, and the normals lowest.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 111 • Number 2 • August 1954

Pages: 139 - 145

PubMed: 13180746

History

Published in print: August 1954

Published online: 1 April 2006

Authors

Details

ALEXANDER SIMON

The Department of Psychiatry, University of California School of Medicine, San Francisco; the Division of Medical Physics, University of California, Berkeley; and The Langley Porter Clinic and Sonoma State Home, Department of Mental Hygiene, State of California.

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CHARLES LUDWIG

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JOHN W. GOFMAN

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G. HAMILTON CROOK

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METABOLIC STUDIES IN MONGOLISM : Serum Protein-Bound Iodine, Cholesterol, and Lipoprotein

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