NEUROSYPHILIS

WILLIAM H. TIMBERLAKEAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 111, Number 7

https://doi.org/10.1176/ajp.111.7.524

Get Access

Abstract

The use of cardiolipin antigen especially in quantitative serologic techniques is highly satisfactory for the diagnosis and in following the course of treatment in syphilis. Persistent positive serology is not an indication for retreatment.

A positive TPI test with a negative serologic test enables one to make a retrospective diagnosis of syphilis. The exceptions to a diagnosis of "false positive" serology when the TPI is negative are the patients whose syphilis was treated in the early stage before TPI antibody could develop and a few patients with obvious late syphilis. When a chronic "false positive" serology has been identified the collagen diseases should be sought.

We still lack a technique that will indicate the survival of treponemes in the host following treatment.

Six-hundred thousand units of procaine penicillin G given daily to a total of 9 million units is the treatment of choice for neurosyphilis. This may be superseded soon by doses of benzyl amine penicillins half this size, and causing fewer side effects.

The major problem of syphilology now is the increasing difficulty of early case finding and control.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 111 • Number 7 • January 1955

Pages: 524 - 527

PubMed: 13228698

History

Published in print: January 1955

Published online: 1 April 2006

Authors

Details

WILLIAM H. TIMBERLAKE

View all articles by this author

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

View Options

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

NEUROSYPHILIS

Abstract

Get full access to this article