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Published Online: September 1959

THE ADMINISTRATION OF BAS, 5-HTP, AND MARSILID TO SCHIZOPHRENIC PATIENTS

AARON FELDSTEIN, HARRY FREEMAN, JUSTIN M. HOPE, IRIS M. DIBNER, and HUDSON HOAGLANDAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 116, Number 3

https://doi.org/10.1176/ajp.116.3.219

Abstract

The administration to 5 chronic schizophrenic patients of BAS alone, of BAS and 5-HTP combined, and of BAS and 5-HTP in conjunction with Marsilid was not therapeutically useful. The fact that the patients did not react to the presumed increase in brain serotonin casts doubt upon the hypothesis that too little or too much serotonin is causally related to schizophrenia.

BAS appears to be a monoamine oxidase inhibitor. The conversion of 5-HTP to 5-HIAA was thus prevented resulting in an accumulation of serotonin in urine.

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Go to American Journal of Psychiatry

Go to American Journal of Psychiatry

American Journal of Psychiatry

Volume 116 • Number 3 • September 1959

Pages: 219 - 221

PubMed: 13822063

History

Published in print: September 1959

Published online: 1 April 2006

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AARON FELDSTEIN

The Worcester Foundation for Experimental Biology, Shrewsbury, Mass., and The Worcester State Hospital, Worcester, Mass.

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HARRY FREEMAN

The Worcester Foundation for Experimental Biology, Shrewsbury, Mass., and The Worcester State Hospital, Worcester, Mass.

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JUSTIN M. HOPE

The Worcester Foundation for Experimental Biology, Shrewsbury, Mass., and The Worcester State Hospital, Worcester, Mass.

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IRIS M. DIBNER

The Worcester Foundation for Experimental Biology, Shrewsbury, Mass., and The Worcester State Hospital, Worcester, Mass.

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HUDSON HOAGLAND

The Worcester Foundation for Experimental Biology, Shrewsbury, Mass., and The Worcester State Hospital, Worcester, Mass.

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