RECURRENT THIOPERAZINE-INDUCED EXTRAPYRAMIDAL REACTION FOLLOWING PLACEBO SUBSTITUTION FOR MAINTENANCE ANTIPARKINSON DRUG

WILLIAM MANDEL, BESSIE CLAFFEY, and LESTER H. MARGOLISAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 118, Number 4

https://doi.org/10.1176/ajp.118.4.351

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Abstract

A placebo was abruptly substituted for maintenance antiparkinson drug in 20 patients who had previously shown evidence of a thioperazine-induced extrapyramidal reaction. Within 20 days of this controlled study extrapyramidal reactions reappeared in 16 patients (80%). The recurrence rate of phenothiazine-induced extrapyramidal reactions following withdrawal of maintenance antiparkinson drug will vary with different situations and their incidence can only be determined by clinical trial.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 118 • Number 4 • October 1961

Pages: 351 - 352

PubMed: 14469190

History

Published in print: October 1961

Published online: 1 April 2006

Authors

Details

WILLIAM MANDEL

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BESSIE CLAFFEY

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LESTER H. MARGOLIS

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Chief of Research, Napa State Hospital, Imola, Calif.

Staff Psychiatrist, Napa State Hospital, Imola, Calif.

Consultant, Napa State Hospital, Imola, Calif.

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RECURRENT THIOPERAZINE-INDUCED EXTRAPYRAMIDAL REACTION FOLLOWING PLACEBO SUBSTITUTION FOR MAINTENANCE ANTIPARKINSON DRUG

Abstract

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