A QUANTITATIVE STUDY OF CHLORPROMAZINE AND ITS SULFOXIDES IN THE URINE OF PSYCHOTIC PATIENTS

CHIEN LI HUANG and ALBERT A. KURLANDAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 118, Number 5

https://doi.org/10.1176/ajp.118.5.428

Get Access

Abstract

A group of 7 chronically ill, male, schizophrenic patients living on the same ward over a period of at least a year were studied. Spectrophotometric measurements of approximately 3,600 urine specimens were performed in order to determine the excretion pattern of free chlorpromazine and the 3 chlorpromazine sulfoxides which were identified on paper chromatograms.

The average excretion of free chlorpromazine and its sulfoxides combined during the period of continuous medication with chlorpromazine at dosage of 100 mg. to 400 mg. t.i.d. ranged from 1.31 to 20.54% of the administered dose. Of this, free chlorpromazine was usually found to be less than 1%, while the sulfoxides ranged from 1 to 18% of the administered dose. The average ratio of free chlorpromazine to its sulfoxides was found to be approximately 1 to 16. After the medication was stopped, free chlorpromazine and its sulfoxides disappeared from the urine within 5 days.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 118 • Number 5 • November 1961

Pages: 428 - 437

PubMed: 14449566

History

Published in print: November 1961

Published online: 1 April 2006

Authors

Details

CHIEN LI HUANG

Research Department, Spring Grove State Hospital, Baltimore 28, Md.

View all articles by this author

ALBERT A. KURLAND

Research Department, Spring Grove State Hospital, Baltimore 28, Md.

View all articles by this author

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

View Options

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

A QUANTITATIVE STUDY OF CHLORPROMAZINE AND ITS SULFOXIDES IN THE URINE OF PSYCHOTIC PATIENTS

Abstract

Get full access to this article