CLINICAL TRIAL OF A NEW ANTIDEPRESSANT (DESIPRAMINE HYDROCHLORIDE) IN A HOSPITAL SETTING

ANTHONY LAPOLLAAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 121, Number 12

https://doi.org/10.1176/ajp.121.12.1206

Get Access

Abstract

Desipramine, the monomethyl metabolite of imipramine, was used as the basic treatment of 20 patients with severe or moderately severe depression. A fixed dose of 50 mg. q.i.d. was given, and drug effects were evaluated in terms of changes in target symptoms, onset of action and side effects.

Complete remission or improvement permitting discharge from hospital was obtained in 14 patients (70%). The time to onset of observable response averaged 2 days, while peak antidepressant action occurred after an average of 5.5 days.

Side effects were encountered in one patient and consisted of gastro-intestinal upset, dry mouth and drowsiness. Medication was discontinued in this case. No significant effects on blood pressure, peripheral blood picture, urine or liver function were observed.

Desipramine appeared to be an effective and well-tolerated antidepressant similar in its activity to imipramine. With the substantial initial dosage used, the relatively prompt onset of action seems to be the prime advantage of the drug in treating serious depressions.

Get full access to this article

View all available purchase options and get full access to this article.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 121 • Number 12 • June 1965

Pages: 1206 - 1208

PubMed: 14286058

History

Published in print: June 1965

Published online: 1 April 2006

Authors

Details

ANTHONY LAPOLLA

Santa Barbara, Calif.

View all articles by this author

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

View Options

Get Access

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

CLINICAL TRIAL OF A NEW ANTIDEPRESSANT (DESIPRAMINE HYDROCHLORIDE) IN A HOSPITAL SETTING

Abstract

Get full access to this article