Reversal of Delirium Induced by Tricyclic Antidepressant Drugs with Physostigmine

JON F. HEISER and DONALD E. WILBERTAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 131, Number 11

https://doi.org/10.1176/ajp.131.11.1275

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Abstract

The authors found that 2 mg. of physostigmine given intramuscularly was effective in reversing acute brain syndromes in two patients who had ingested toxic doses of drugs with anticholinergic properties (amitriptyline alone and an amitriptyline-perphenazine combination). Physostigmine also controlled one patient's tachycardia and tachypnea. Physostigmine may not control toxic effects of anticholinergic drugs when these effects are not mediated through cholinergic blockade.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 131 • Number 11 • November 1974

Pages: 1275 - 1277

PubMed: 4424019

History

Published in print: November 1974

Published online: 12 February 2015

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JON F. HEISER

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DONALD E. WILBERT

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Assistant Adjunct Professor, Department of Psychiatry and Human Behavior, California College of Medicine, University of California, Irvine and Assistant Chief, Adult Psychiatric Inpatient Service, Orange County Medical Center, Orange, Calif. 92668

Clinical Instructor, Department of Psychiatry and Human Behavior, California College of Medicine, University of California, Irvine and Staff Psychiatrist, Adult Psychiatric Inpatient Service, Orange County Medical Center, Orange, Calif. 92668

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Reversal of Delirium Induced by Tricyclic Antidepressant Drugs with Physostigmine

Abstract

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