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Published Online: June 1974

Studies of EN-1639A (Naltrexone): A New Narcotic Antagonist

RICHARD B. RESNICK, JAN VOLAVKA, ALFRED M. FREEDMAN, and MURIEL THOMASAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 131, Number 6

https://doi.org/10.1176/ajp.131.6.646

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Abstract

The narcotic antagonist EN-1639A (naltrexone) was studied in 37 heroin addicts and found to be clinically useful, with a low incidence of side effects, lack of toxicity, high degree of acceptability to the patient, and capacity to antagonize the euphoric effects of heroin for up to 72 hours after a single oral dose. These findings provide a basis for expanding studies of the clinical efficacy of naltrexone in the treatment of opiate dependence.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 131 • Number 6 • June 1974

Pages: 646 - 650

PubMed: 4827793

History

Published in print: June 1974

Published online: 12 February 2015

Authors

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RICHARD B. RESNICK

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JAN VOLAVKA

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ALFRED M. FREEDMAN

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MURIEL THOMAS

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Assistant Professor, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

Associate Professor, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

Professor and Chairman, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

Instructor, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

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Studies of EN-1639A (Naltrexone): A New Narcotic Antagonist

Abstract

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