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Published Online: June 1974

Affective State and Thyrotropin and Prolactin Responses After Repeated Injections of Thyrotropin-Releasing Hormone in Depressed Patients

Publication: American Journal of Psychiatry

Abstract

Eight patients with serious depression were given 1000 µg. of thyrotropin-releasing hormone (TRH) or saline intravenously for three days in a double-blindstudy. All patients then received 1000 µg. of TRH daily for the next seven days. The group receiving saline showed the greatest improvement; only one patient improved substantially while receiving TRH. Plasma thyrotropin and prolactin responses to TRH were distinctly diminished in three of the most severely depressed patients. The authors suggest that in depression the primary value of TRH may be as a diagnostic tool in differentiating among various types of depression.

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Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 714 - 718
PubMed: 4208055

History

Published in print: June 1974
Published online: 12 February 2015

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Clinical Assistant Professor of Psychiatry, Louisiana State University School of Medicine, New Orleans, La.
Chief of Endocrinology, Veterans Administration Hospital, and Associate Professor of Medicine, Tulane University School of Medicine, New Orleans, La.
Associate Professor, Department of Medicine, University of Rochester School of Medicine, Rochester, N. Y.
Chairman, Department of Physiology, University of Manitoba, Winnipeg, Man., Canada
Chief, Endocrine and Polypeptide Laboratory, Veterans Administration Hospital, and Professor, Department of Medicine, Tulane University School of Medicine, New Orleans, La.

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