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Published Online: October 1961

A "DOUBLE BLIND" STUDY COMPARING RO 4-0403, TRIFLUOPERAZINE AND A PLACEBO IN CHRONICALLY ILL MENTAL PATIENTS

ANTIOCO BARRON, BARBARA BECKERING, LESTER H. RUDY, and JACKSON A. SMITHAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 118, Number 4

https://doi.org/10.1176/ajp.118.4.347

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Abstract

1. RO 4-0403 (Taractan) produced a beneficial response in 7 of a group of 30 extremely chronic psychotic patients. Those patients who responded showed a decrease in agitation, appeared more friendly and expressed the subjective sensation of "feeling better." Undesirable side effects were observed in only 2 of the 30 patients treated. From these results it would appear that this compound can be safely and effectively used in acute psychiatric disorders.

2. Trifluoperazine (Stelazine) is a potent drug that is effective in reducing the symptomatology in chronic psychotic patients. In this study more than half the patients who received trifluoperazine showed a desirable change of behavior during the study but side effects were noted in 40% of those treated. These side effects usually appeared at a high dosage and disappeared promptly after the administration of anti-Parkinsonian drugs.

3. Since only 1 patient out of 30 showed a slight improvement while receiving a placebo, it is presumed that suggestion and attention were of minimal importance in producing the changes observed with the active compounds.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 118 • Number 4 • October 1961

Pages: 347 - 348

History

Published in print: October 1961

Published online: 1 April 2006

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Details

ANTIOCO BARRON

Staff of the Illinois State Psychiatric Institute, Chicago, Illinois.

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BARBARA BECKERING

Staff of the Illinois State Psychiatric Institute, Chicago, Illinois.

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LESTER H. RUDY

Staff of the Illinois State Psychiatric Institute, Chicago, Illinois.

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JACKSON A. SMITH

Staff of the Illinois State Psychiatric Institute, Chicago, Illinois.

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A "DOUBLE BLIND" STUDY COMPARING RO 4-0403, TRIFLUOPERAZINE AND A PLACEBO IN CHRONICALLY ILL MENTAL PATIENTS

Abstract

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