A COMPARISON OF TWO PHENOTHIAZINES IN THE TREATMENT OF SCHIZOPHRENICS

M. DIERKSAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 119, Number 8

https://doi.org/10.1176/ajp.119.8.775

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Abstract

Consecutive evaluations of trifluoperazine and thioridazine were performed in 109 hospitalized schizophrenics. The same degree of tranquilizing effect was obtained with both drugs in 104 patients. Extrapyramidal symptoms were induced by thioridazine in 1 patient and by trifluoperazine in 79 patients and were controlled by the addition of benztropine.

This study has demonstrated that thioridazine is an affective agent relatively free of extrapyramidal symptoms and that the latter are not required for a drug to be an efficient tranquilizer. In addition, treatment with thioridazine alone required fewer tablets per day and resulted in greater economy as well as increased assurance of drug intake and patient cooperation.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 119 • Number 8 • February 1963

Pages: 775 - 776

PubMed: 14027786

History

Published in print: February 1963

Published online: 1 April 2006

Authors

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M. DIERKS

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A COMPARISON OF TWO PHENOTHIAZINES IN THE TREATMENT OF SCHIZOPHRENICS

Abstract

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