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Published Online: March 1966

BIOCHEMICAL STUDIES OF FAMILIES OF SCHIZOPHRENIC PATIENTS

THOMAS M. SULLIVAN, CHARLES E. FROHMAN, PETER G. S. BECKETT, and JACQUES S. GOTTLIEBAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 122, Number 9

https://doi.org/10.1176/ajp.122.9.1040

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Abstract

Thirty-five schizophrenic patients were separated into two groups on the basis of L/P ratio studies. Twenty-one patients manifested an increased plasma protein factor as reflected by a mean L/P ratio above 11.5—the high-factor group. Fourteen patients showed no increase in protein factor as evidenced by a mean L/P ratio below 11.5—the low-factor group.

L/P ratio determinations were made on 117 parents and siblings of both the high- and low-factor groups of patients. There is a significantly greater proportion of high L/P ratios in families of the high-factor patients than in families of low-factor patients.

The data, while demonstrating a familial trend, are not sufficiently definitive to allow a specific genetic interpretation. Previous studies have indicated that environmental factors might also play a significant role.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 122 • Number 9 • March 1966

Pages: 1040 - 1044

PubMed: 5903245

History

Published in print: March 1966

Published online: 1 April 2006

Authors

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THOMAS M. SULLIVAN

Lafayette Clinic, 951 E. Lafayette, Detroit, Mich. and Wayne State University College of Medicine, Detroit

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CHARLES E. FROHMAN

Lafayette Clinic, 951 E. Lafayette, Detroit, Mich. and Wayne State University College of Medicine, Detroit

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PETER G. S. BECKETT

Lafayette Clinic, 951 E. Lafayette, Detroit, Mich. and Wayne State University College of Medicine, Detroit

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JACQUES S. GOTTLIEB

Lafayette Clinic, 951 E. Lafayette, Detroit, Mich. and Wayne State University College of Medicine, Detroit

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BIOCHEMICAL STUDIES OF FAMILIES OF SCHIZOPHRENIC PATIENTS

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