A Dimethyltryptamine-Forming Enzyme in Human Blood

RICHARD J. WYATT, JUAN M. SAAVEDRA, and JULIUS AXELRODAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 130, Number 7

https://doi.org/10.1176/ajp.130.7.754

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Abstract

An enzyme capable of forming the hallucinogen dimethyltryptamine was found in human red blood cells, plasma, and platelets. The enzyme activity in red blood cells and plasma was not significantly different in psychiatric patients from that in normal subjects. The enzyme activity in platelets was higher in psychotic subjects than in nonpsychotics and was apparently related to the presence of a dialyzable inhibitor in the normal subjects.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 130 • Number 7 • July 1973

Pages: 754 - 760

PubMed: 4514540

History

Published in print: July 1973

Published online: 1 April 2006

Authors

Details

RICHARD J. WYATT

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JUAN M. SAAVEDRA

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JULIUS AXELROD

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Acting Chief, Laboratory of Clinical Psychopharmacology, Saint Elizabeths Hospital, Washington, D.C. 20032, National Institute of Mental Health

NIH International Postdoctoral Fellow, National Institute of Mental Health

Chief of the Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health

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A Dimethyltryptamine-Forming Enzyme in Human Blood

Abstract

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