Fluphenazine Enanthate and Fluphenazine Decanoate: A Comparison of Their Duration of Action and Motor Side Effects

H. M. VAN PRAAG and L. C. W. DOLSAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 130, Number 7

https://doi.org/10.1176/ajp.130.7.801

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Abstract

Fluphenazine enanthate and fluphenazine decanoate—two long-acting neuroleptics—were administered in a controlled comparative study to 30 patients with acute psychoses of different character and origin. The study compared the duration of action and affinity for the extrapyramidal system of the two drugs. The decanoate ester acted longer than the enanthate ester and provoked fewer motor side effects. Since these side effects greatly reduce the patient's motivation to cooperate in taking depot medication, the decanoate ester is to be preferred.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 130 • Number 7 • July 1973

Pages: 801 - 804

PubMed: 4576449

History

Published in print: July 1973

Published online: 1 April 2006

Authors

Affiliations

H. M. VAN PRAAG

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L. C. W. DOLS

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Professor of Biological Psychiatry, Department of Biological Psychiatry, Psychiatric University Clinic, 59 Oostersingel, Groningen, the Netherlands

Research Assistant, Department of Biological Psychiatry, Psychiatric University Clinic, 59 Oostersingel, Groningen, the Netherlands

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Fluphenazine Enanthate and Fluphenazine Decanoate: A Comparison of Their Duration of Action and Motor Side Effects

Abstract

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