The Tranylcypromine Isomers : A Controlled Clinical Trial

JAVIER I. ESCOBAR, BURTRUM C. SCHIELE, and ROBERT ZIMMERMANNAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 131, Number 9

https://doi.org/10.1176/ajp.131.9.1025

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Abstract

The plus (+ ) and minus (–) isomers of tranylcypromine (Parnate) were tested under double-blind conditions on 11 depressed patients. The (—) isomer was the more effective and produced fewer side effects. Because the (–) isomer has been shown to be a stronger blocker of the reuptake mechanism for brain amines and a weaker inhibitor of monoamine oxidase than the (+) isomer, the results obtained here are of particular interest.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 131 • Number 9 • September 1974

Pages: 1025 - 1026

PubMed: 4607266

History

Published in print: September 1974

Published online: 12 February 2015

Authors

Details

JAVIER I. ESCOBAR

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BURTRUM C. SCHIELE

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ROBERT ZIMMERMANN

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Dr. Escobar s Assistant Professor, Department of Psychiatry, University of Minnesota at St. Paul-Ramsey Hospital and Medical Center, 640 Jackson St., St. Paul, Minn. 55101

Professor Emeritus of Psychiatry, University of Minnesota Medical School, Minneapolis, Minn. and Consultant, Adult Psychiatry Unit, St. Paul-Ramsey Hospital and Medical Center

Research Associate, Research Unit, Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minn.

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The Tranylcypromine Isomers : A Controlled Clinical Trial

Abstract

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