Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population
Abstract
Objective:
Methods:
Results:
Conclusions:
Methods
Study Sample
Image Acquisition and Preprocessing
Identifying the Presence of Schizophrenia Imaging Signatures and Defining Subgroups
Voxel-Wise Volumetric Analyses
Clinical and Cognitive Measures
Genetic Measures
Statistical Analysis
Results
Replication of Schizophrenia Neuroanatomical Subtypes
Prevalence of Schizophrenia Imaging Signatures in the PNC
![](/cms/10.1176/appi.ajp.21070686/asset/images/large/appi.ajp.21070686f1.jpeg)
Associations Between Signature 1, Signature 2, Cognition, and Psychosis Spectrum Symptoms in the PNC
![](/cms/10.1176/appi.ajp.21070686/asset/images/large/appi.ajp.21070686f2.jpeg)
Prevalence of Schizophrenia Imaging Signatures in the UK Biobank
![](/cms/10.1176/appi.ajp.21070686/asset/images/large/appi.ajp.21070686f3.jpeg)
Associations Between Signature 1, Signature 2, and Cognition in the UK Biobank
![](/cms/10.1176/appi.ajp.21070686/asset/images/large/appi.ajp.21070686f4.jpeg)
Genetic Associations of Signature 1 and Signature 2 in the UK Biobank
![](/cms/10.1176/appi.ajp.21070686/asset/images/large/appi.ajp.21070686f5.jpeg)
Discussion
Prevalence of Schizophrenia Neuroanatomical Signatures and Their Significance
Differences Between Signatures
Limitations
Conclusions
Footnotes
Supplementary Material
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References
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