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Published Online: June 1964

INTERCHANGEABILITY OF ANTIPARKINSONIAN MEDICATION

A. ST. JEAN, M. DONALD, and T. A. BANAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 120, Number 12

https://doi.org/10.1176/ajp.120.12.1189

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Abstract

In this study, conducted on 30 mental hospital patients manifesting extrapyramidal symptomatology, two antiparkinsonian drugs were interchanged with one another and with a placebo in a double-blind, crossover trial, and the results compared with a third antiparkinsonian drug used as a positive control. Physical and laboratory information was collected as well as ratings on psychiatric and extrapyramidal symptomatology.

In all subgroups, the extrapyramidal symptom ratings were significantly higher (p>.005) when receiving placebo than when receiving promethazine, ethopropazine or trihexyphenidyl. This would indicate the effectiveness of these drugs in controlling extrapyramidal symptomatology as well as the inadequacy of placebo treatment in cases of overt extrapyramidal symptomatology.

There were no significant changes in physical and laboratory measures, nor in ratings of psychiatric symptoms under any of the experimental conditions.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 120 • Number 12 • June 1964

Pages: 1189 - 1190

PubMed: 14154754

History

Published in print: June 1964

Published online: 1 April 2006

Authors

Affiliations

A. ST. JEAN

Hôpital des Laurentides, L'Annonciation, Quebec.

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M. DONALD

Hôpital des Laurentides, L'Annonciation, Quebec.

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T. A. BAN

Hôpital des Laurentides, L'Annonciation, Quebec.

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INTERCHANGEABILITY OF ANTIPARKINSONIAN MEDICATION

Abstract

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