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Published Online: August 1967

Two Varieties of Plasma Imipramine Curves in Psychotic Depressions and Normal Controls

GEORGE G. HAYDU, ANDREAS DHRYMIOTIS, and GERTRUDE P. QUINNAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 124, Number 2

https://doi.org/10.1176/ajp.124.2.257

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Abstract

Plasma imipramine determinations were done in 29 newly hospitalized patients with psychotic depression and in nine normal controls after single oral administrations of 100 mg. of the drug. Two types of curves were found which differed significantly at seven and 24 hours after drug administration.

Patients with low oral curves (type A) also had significantly lower plasma imipramine at two hours after intramuscular administration than patients with high oral curves (type B) had. All patients with psychotic involutional depression, as well as normal controls (with one exception), exhibited type A curve. Patients evidencing depressions with manic-depressive psychoses had mainly type B curves.

The results are discussed from the point of view of drug binding and metabolism differing according to the functional condition of the central nervous system in the depressions.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 124 • Number 2 • August 1967

Pages: 257 - 260

PubMed: 4951590

History

Published in print: August 1967

Published online: 1 April 2006

Authors

Affiliations

GEORGE G. HAYDU

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ANDREAS DHRYMIOTIS

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GERTRUDE P. QUINN

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Principal Research Scientist at the Creedmoor Institute for Psychobiologic Studies, Department of Mental Hygiene, Creedmoor State Hospital, Queens Village, N. Y. 11427

Department of Mental Hygiene, Creedmoor State Hospital, Queens Village, N. Y. 11427

Geigy Research Laboratories, Yonkers, N. Y.

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Two Varieties of Plasma Imipramine Curves in Psychotic Depressions and Normal Controls

Abstract

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