Effects of Imipramine on Individuals Varying in Level of Depression

In the belief that studies with normal subjects are relevant to the assessment of psychotropic drugs for clinical use, the authors examined the antidepressant and anti-anxiety effects of imipramine in a group of nonhospitalized, asymptomatic subjects selected to differ in level of (nonclinical) depression. Although some of the results might be termed paradoxical, it was demonstrated that the antidepressant property of the drug, for which it is clinically utilized, is also evident in normal subjects.