American Journal of Psychiatry

Publication date: 01 February 1968

The author attempts to construct a model for patient assessment and psychiatric drug therapy akin to that of somatic therapy. It is suggested that drug effects on major target functions of behavior can form a basis for their rational selection and use and ...

Publication date: 01 February 1968

Drugs may be a useful adjunct to psychotherapy in the treatment of the neuroses, affording the patient a measure of symptom relief so that he can cope with his problems more efficiently. The author stresses, however, that appropriate drug treatment ...

Publication date: 01 February 1968

Drugs are equally important in the treatment of disturbed children as in the treatment of adults. Drug therapy modifies appropriate target symptoms and facilitates the other aspects of treatment. Specific indications and limitations are discussed, as well ...

Publication date: 01 February 1968

To test the validity of current assumptions about the relationship between the patient's attitude toward drug therapy and his clinical response to it, a double-blind study was conducted with 20 outpatients. The author found that treatment outcome, as ...

Publication date: 01 February 1968

Since 1959 a growing number of reports have described a new type of neurological disorder in mental patients. This disorder, known as tardive dyskinesia, has been observed in approximately 500 cases but, judging from the accurate observations made by ...

Publication date: 01 February 1968

This author's inspection of the literature on oral dyskinesia following prolonged phenothiazine administration reveals that many of the cases reported do not meet the criteria necessary to establish the existence of a tardive, irreversible syndrome. He ...

Publication date: 01 February 1968

In the belief that studies with normal subjects are relevant to the assessment of psychotropic drugs for clinical use, the authors examined the antidepressant and anti-anxiety effects of imipramine in a group of nonhospitalized, asymptomatic subjects ...

Publication date: 01 February 1968

A double-blind trial was conducted on 100 depressed patients using amitriptyline and its derivative, nortriptyline. Scores obtained on the Hamilton Depression Scale were used as an index of change. Patients treated with nortriptyline responded ...