American Journal of Psychiatry

Substance use disorder (SUD) is common in psychiatric patients and has a negative impact on health and well-being. However, SUD often goes untreated, and there is a need for psychiatrists, of all specialties, to address this pervasive clinical problem. In ...

https://doi.org/10.1176/appi.ajp.20231023

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Disparities in Treatment for Alcohol Use Disorder Among All of Us Participants

Publication date: 01 November 2024

Pages973–987

Objective: The authors examined racial/ethnic and socioeconomic disparities in receiving treatment for alcohol use disorder (AUD). Methods: A retrospective cohort study was conducted that included adults (≥18 years) with AUD from the All of Us Controlled ...

https://doi.org/10.1176/appi.ajp.20230730

Association of Cannabis Use Reduction With Improved Functional Outcomes: An Exploratory Aggregated Analysis From Seven Cannabis Use Disorder Treatment Trials to Extract Data-Driven Cannabis Reduction Metrics

Publication date: 09 October 2024

Pages988–996

Objective: This exploratory analysis sought to determine whether decreases in cannabis use are associated with improvements in cannabis-related problems and functional outcomes, and if so, what percentage decrease is associated with improvement. Methods: ...

https://doi.org/10.1176/appi.ajp.20230508

Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women

Publication date: 09 October 2024

Pages997–1005

Objective: Midbrain dopamine function plays a key role in translational models of substance use disorders. Whether midbrain dopamine function is associated with substance use frequency and severity or reward function in 20–24 year-olds remains a critical ...

https://doi.org/10.1176/appi.ajp.20220819

Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors

Publication date: 09 October 2024

Pages1006–1017

Objective: Increasingly large samples in genome-wide association studies (GWASs) for alcohol use behaviors (AUBs) have led to an influx of implicated genes, yet the clinical and functional understanding of these associations remains low, in part because ...

https://doi.org/10.1176/appi.ajp.20231055