Enhancing the Tolerability of Tacrine With Propantheline

Mr. A, 72 years old, had a 4-year history of failing memory, losing objects at home, and neglecting his hygiene and grooming. He had prominent executive dysfunction and impaired memory. A computerized tomography (CT) scan revealed mild brain atrophy, and a single photon emission CT (SPECT) scan showed bilateral temporoparietal, posterior frontal, and right cerebellar hypoperfusion consistent with his clinical diagnosis of probable Alzheimer’s disease. He tolerated tacrine up to 120 mg/day without gastrointestinal upset. At 160 mg/day, however, he complained of substantial nausea, which resolved with the addition of propantheline, 7.5 mg, before each 40-mg tacrine dose.

Mr. B was 49 years old when diagnosed with possible Alzheimer’s disease. He had progressive memory impairment unexplained by his medical workup, including brain magnetic resonance imaging (MRI). He had a positive response to tacrine, 20 mg q.i.d., without any side effects. A dose increase to 30 mg q.i.d. caused severe nausea and vomiting, necessitating a return to 20 mg q.i.d. Several months later, with the addition of propantheline, 7.5 mg 30 minutes beforehand, he tolerated tacrine, 30 mg q.i.d., without any discomfort.

Mr. C was 49 years old when referred for memory difficulties, which led to his forced retirement as a teacher. He was diagnosed with probable Alzheimer’s disease following evidence of memory and executive dysfunctions and bilateral parieto-occipital hypoperfusion on a brain SPECT scan. At referral he was already receiving tacrine, 40 mg q.i.d., and paroxetine, 20 mg/day, but he complained of nausea, gas, and gastrointestinal upset, especially after taking tacrine on an empty stomach. He often skipped his last scheduled tacrine dose because of these side effects. Propantheline, 15 mg 30 minutes before each tacrine dose, controlled all gastrointestinal complaints.

Mr. D was 75 years old when diagnosed with probable Alzheimer’s disease following 1 year of cognitive decline and executive dysfunction. His MRI revealed diffuse brain atrophy, and a SPECT scan showed bitemporal and biparietal hypoperfusion. He was treated concurrently with tacrine and propantheline, 15 mg 30 minutes before tacrine. Because of a robust response to tacrine, 20 mg q.i.d., he and his wife refused further dose escalation. They noted that when he omitted the propantheline, he experienced significant nausea and vomiting following each tacrine dose.