American Journal of Psychiatry
- Volume 156
- Number 1
- January 1999
Editorial
Images In Neuroscience
Special Article
Publication date: 01 January 1999
Pages5–10OBJECTIVE: Policy and clinical management decisions depend on data on the health and cost impacts of psychiatric treatments under usual care, i.e., effectiveness. Clinical trials, however, provide information on treatment efficacy under best-practice ...
https://doi.org/10.1176/ajp.156.1.5Regular Article
Publication date: 01 January 1999
Pages11–18OBJECTIVE: Since signals for cocaine induce limbic brain activation in animals and cocaine craving in humans, the objective of this study was to test whether limbic activation occurs during cue-induced craving in humans. METHOD: Using positron emission ...
https://doi.org/10.1176/ajp.156.1.11Publication date: 01 January 1999
Pages19–26OBJECTIVE: The authors have shown that decreases in dopamine D2 receptors in cocaine abusers were associated with decreased metabolism in the cingulate and prefrontal and orbitofrontal cortices. To assess whether increasing dopamine would reverse these ...
https://doi.org/10.1176/ajp.156.1.19Publication date: 01 January 1999
Pages27–33OBJECTIVE: This study examined the differential efficacy and relative costs of two intensities of adjunctive psychosocial services—a day treatment program and enhanced standard care—for the treatment of opioid-dependent patients maintained on methadone ...
https://doi.org/10.1176/ajp.156.1.27Publication date: 01 January 1999
Pages34–40OBJECTIVE: Most twin and adoption studies of alcoholism have ascertained cases through treatment settings or archival data; these subjects may differ from affected subjects identified epidemiologically. The authors studied the importance of genetic ...
https://doi.org/10.1176/ajp.156.1.34Publication date: 01 January 1999
Pages41–49OBJECTIVE: The DSM-IV work group asked researchers and clinicians to subtype substance dependent individuals according to the presence or absence of physiological symptoms. A recent report from the Collaborative Study on the Genetics of Alcoholism ...
https://doi.org/10.1176/ajp.156.1.41Publication date: 01 January 1999
Pages50–57OBJECTIVE: The primary goal of this study was to evaluate increased platelet membrane fluidity as a putative risk factor for Alzheimer’s disease and its relationship to the APOE ε4 genotype. METHOD: This report describes the results of a prospective, ...
https://doi.org/10.1176/ajp.156.1.50Publication date: 01 January 1999
Pages58–65OBJECTIVE: The epidemiology of cognitive decline over 11.5 years was investigated in a large community-residing population, with a special emphasis on the relationship between education and cognitive decline. METHOD: The study was an 11.5-year follow-up ...
https://doi.org/10.1176/ajp.156.1.58Publication date: 01 January 1999
Pages66–71OBJECTIVE: The goal of this study was to determine the frequency of physically aggressive behavior in community-residing patients with dementia and its relationship to depression. METHOD: A consecutive series of 541 patients with DSM-IV-defined dementia ...
https://doi.org/10.1176/ajp.156.1.66Publication date: 01 January 1999
Pages72–78OBJECTIVE: Several postmortem studies have reported a decreased density of serotonin 5-HT2 receptors in the prefrontal cortex in schizophrenia. The purpose of this study was to investigate this in patients with schizophrenia by means of [18F]setoperone ...
https://doi.org/10.1176/ajp.156.1.72Publication date: 01 January 1999
Pages79–87OBJECTIVE: It has been hypothesized that the morbidity and mortality associated with schizophrenia can be prevented by providing effective treatment during the first episode of psychosis. Hence, the authors examined patients with first-episode psychosis ...
https://doi.org/10.1176/ajp.156.1.79Publication date: 01 January 1999
Pages88–93OBJECTIVE: This study compared the effect of clozapine and haloperidol on positive and negative symptoms of schizophrenia and in patients with high levels of negative symptoms or the deficit syndrome. METHOD: Patients were participants in a 15-site double-...
https://doi.org/10.1176/ajp.156.1.88Publication date: 01 January 1999
Pages94–100OBJECTIVE: As physician-assisted suicide is debated, a need for standardized measurement of desire for death among medically ill individuals has emerged. The authors present preliminary validation data for a new self-report instrument, the Schedule of ...
https://doi.org/10.1176/ajp.156.1.94Publication date: 01 January 1999
Pages101–107OBJECTIVE: The goals of this study were to determine whether fluoxetine is superior to placebo in treating HIV-seropositive patients with major depression or dysthymia or both, whether severity of immunosuppression is associated with treatment response, ...
https://doi.org/10.1176/ajp.156.1.101Publication date: 01 January 1999
Pages108–114OBJECTIVE: It is unclear whether the additional benefits of receiving depression treatment from mental health specialists in routine care pays for the additional costs, compared with treatment delivered by general medical providers. This study examines ...
https://doi.org/10.1176/ajp.156.1.108Publication date: 01 January 1999
Pages115–123OBJECTIVE: The authors present nationally representative descriptive data on 12-month use of outpatient services for psychiatric problems. They focused on the relationship between DSM-III-R disorders and service use in four broadly defined service sectors ...
https://doi.org/10.1176/ajp.156.1.115Clinical Case Conference
Images In Psychiatry
Brief Report
Publication date: 01 January 1999
Pages130–132OBJECTIVE: To screen for dopaminergic abnormalities in tobacco smokers and patients with posttraumatic stress disorder (PTSD), the authors determined serial CSF and plasma concentrations of the dopamine metabolite homovanillic acid (HVA). METHOD: ...
https://doi.org/10.1176/ajp.156.1.130Publication date: 01 January 1999
Pages133–135OBJECTIVE: The authors’ goal was to examine the relationship between subclinical depressive symptoms in adolescence and major depressive episodes in adulthood. METHOD: An epidemiologic sample of 776 young people received psychiatric assessments in 1983, ...
https://doi.org/10.1176/ajp.156.1.133Publication date: 01 January 1999
Pages136–138OBJECTIVE: This study examined the putative role of serotonin genes in the etiology of bipolar affective disorder. METHOD: Genetic association analysis was performed for individuals with bipolar affective disorder and unaffected subjects closely matched ...
https://doi.org/10.1176/ajp.156.1.136Publication date: 01 January 1999
Pages139–141OBJECTIVE: The authors examined whether Continuous Performance Test scores correlate with frontosubcortical volumes in bipolar disorder. METHOD: The subjects were 17 patients hospitalized for an acute manic episode and 12 group-matched comparison ...
https://doi.org/10.1176/ajp.156.1.139Publication date: 01 January 1999
Pages142–144OBJECTIVE: The authors examined the efficacy of intramuscular flunitrazepam compared with intramuscular haloperidol for the immediate control of agitated or aggressive behavior in acutely psychotic patients. METHOD: Twenty-eight actively psychotic ...
https://doi.org/10.1176/ajp.156.1.142Publication date: 01 January 1999
Pages145–147OBJECTIVE: The focus of this study was the systematic evaluation of the clinical effects of glycine as an adjunct to the atypical antipsychotic clozapine in the treatment of schizophrenia. METHOD: In a double-blind, placebo-controlled study, 19 patients ...
https://doi.org/10.1176/ajp.156.1.145Book Forum: HEALTH ECONOMICS AND OUTCOME MEASURES
Book Forum: CHILD PSYCHIATRY AND DEVELOPMENTAL DISORDERS
Book Forum: WOMEN’S HEALTH
Book Forum: SUBSTANCE USE AND ABUSE
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