High Frequency of Dysphoric Reactions to Tetrahydrocannabinol Among Depressed Patients

Steven L. Ablon, M.D., and Frederick K. Goodwin, M.D.Authors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 131, Number 4

https://doi.org/10.1176/ajp.1974.131.4.448

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Abstract

This study reports a high incidence of dysphoric reactions to Δ⁹-tetrahydrocannabinol (THC) administered under double-blind conditions to a well-defined homogeneous population of hospitalized patients with unipolar depressive illness. Personality characteristics that might predispose patients to dysphoric reactions are examined and the implications of the effect of THC on the mood of depressed patients are discussed.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 131 • Number 4 • April 1974

Pages: 448 - 453

PubMed: 4592555

History

Published in print: April 1974

Published online: 24 April 2020

Authors

Details

Steven L. Ablon, M.D.

The authors were formerly both with the Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. 20014, where Dr. Goodwin is Chief. Dr. Ablon is now a Fellow in Child Psychiatry, Children’s Center, McLean Hospital, Belmont, Mass. Address reprint requests to Dr. Goodwin.

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Frederick K. Goodwin, M.D.

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High Frequency of Dysphoric Reactions to Tetrahydrocannabinol Among Depressed Patients

Abstract

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