Cytokines and the Brain: Implications for Clinical Psychiatry
Abstract
Structure and Function of Cytokines
Major Properties of Cytokines
Classification of Cytokines
Proinflammatory cytokines
Antiinflammatory cytokines
Hematopoietic cytokines
Cytokines and Immunogenetics
Quantitative Assessment of Cytokines
Immunoassays
Bioassays
Cytokines and Neuroimmunology
Cytokine Localization in the Brain
Cytokines and Associated Brain Activities
Immunologic effects
Neurochemical effects
Neuroendocrine effects
Behavioral effects
Stress and Cytokine Secretion
Cytokines and Psychiatric Disorders
Major Depression
Schizophrenia
Alzheimer’s Disease and Other Psychiatric Disorders
Cytokines and Consultation-Liaison Psychiatry
Use of Cytokines in Selected Medical Conditions
Administration of exogenous cytokines
Inhibition of cytokines
Psychiatric Adverse Effects of Treatment With Cytokines
Interferon
IL-2 and lymphokine-activated killer cells
Other cytokines
Anticytokine therapy
Effects of Psychiatric Treatment on Cytokine Production
Conclusions
Footnote
References
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