Aripiprazole in a Patient Vulnerable to Side Effects

Ms. A, a 19-year-old patient, had suffered from motor and vocal tics since the age of 6. Her vocal tics included grunting, snorting, neighing, palilalia, and motor tics, such as beating and strangling herself. Additionally, she developed compulsions of washing and controlling. The course of her illness was chronic, not waxing and waning. She had experienced no tic-free interval during the last 13 years. Pharmacotherapy over the last years included 300 mg/day of tiapride, leading to an improvement of her motor tics only. Additional therapy with 300 mg/day of sulpiride first and 400 mg/day of amisulpride later each caused galactorrhea, without substantial therapeutic effect. Ms. A stopped taking both substances. Ms. A also stopped taking 4 mg/day of pimozide and later 80 mg/day of ziprasidone, each taken over several weeks; both caused amenorrhea and had only marginal effects on the tics.

Afterward, we started treatment with 10 mg/day of aripiprazole because of the side effect profile. In the first week, Ms. A’s motor and vocal tics showed a marked improvement; after 2 weeks, Ms. A was nearly tic free for the first time in 13 years. Amenorrhea or galactorrhea was not present during the next months; other side effects, such as sedation or weight gain, did not occur. Ms. A started working as a waiter for the first time. The compulsions were much improved. Only a blinking tic, which exacerbated during stress, persisted.