Naltrexone Effects in Patients With Dementia
“Mr. S” was an 84-year-old man with long-standing bipolar I disorder and alcoholism. He had developed dementia as a result of Alzheimer's disease. His persistent alcoholism included consumption of up to one-fifth of whiskey daily, which led to bizarre and dangerous behaviors. He began naltrexone (50 mg daily), which resulted in reduced interest in alcohol within the first week. This improvement was sustained even after treatment was discontinued 6 months later.“Ms. A” was an 86-year-old woman with frontotemporal dementia who repeatedly drank scotch to intoxication, resulting in frequent falls. Bottles of liquor were stashed throughout her house, and she became acutely agitated if she was prevented from buying more. While receiving treatment with naltrexone (50 mg daily), the forcefulness of her alcohol-seeking behavior abated, and after 3 weeks she discontinued drinking altogether. Naltrexone was continued for a full year, with continued sobriety.“Mr. C” was a 68-year-old man with Wernicke-Korsakoff syndrome. He was able to live independently with a supportive landlord, but placement in a secure facility was considered after several hospitalizations resulted from his drinking to unconsciousness. While receiving treatment with naltrexone (50 mg), he discontinued frequenting local bars and was able to continue living in his familiar neighborhood.
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