A Genome Scan for Loci Shared by Autism Spectrum Disorder and Language Impairment
Abstract
Objective
Method
Results
Conclusion
Method
Overview of Design
Genotyping
Statistical Analysis
Overall data analysis plan.
Linkage/association analysis methods.
Statistical correction for multiple phenotypes.
Results
Initial Linkage Results for Language
Maximizing Model | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Estimated Genotypic Effect for Locusc | |||||||||||
Phenotype | Chromosome | cM | PPL | Band Range | Width (Mb) | Fully Maximized Lod Scoreb | −/− | +/− | +/+ | Disease Gene Frequency | Heterogeneity Parameter in Admixture Likelihood (α)d |
Yale-Brown Obsessive Compulsive Scale | 13 | 58 | 0.36 | q14.3–21.3 | 17.3 | 4.2 | –3.0 | 0.00 | 3.00 | 0.300 | 0.7 |
Social Responsiveness Scale dichotomous trait | 14 | 117 | 0.37 | q32.2–32.23 | 7.6 | 3.5 | 0.0 | 0.10 | 0.80 | 0.100 | 1.0 |
LI* traite | 15 | 83 | 0.57 | q23–26.2 | 24.2 | 4.1 | 0.0 | 0.70 | 0.99 | 0.001 | 1.0 |
Social Responsiveness Scale quantitative trait | 15 | 120 | 0.52 | q26.2–26.3 | 6.2 | 4.5 | –2.0 | 1.00 | 2.00 | 0.100 | 0.9 |
RI* traite | 16 | 43 | 0.36 | p12.1–12.3 | 8.9 | 4.6 | 0.0 | 0.00 | 0.90 | 0.200 | 1.0 |
Further Characterization of the Roles of Language and Autism at Linked Loci
Linkage Analysis of Nonlanguage Phenotypes
Genome-Wide Association Analysis
Discussion
Acknowledgments
Supplementary Material
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