American Journal of Psychiatry

Psychotherapies focusing on relationships and separation anxiety may be helpful for adults with anxiety disorders who experienced separation anxiety in childhood. The fear extinction model of anxiety calls for desensitization to threatening stimuli and ...

https://doi.org/10.1176/appi.ajp.2013.13060781

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A Double-Blind Randomized Controlled Trial of Augmentation and Switch Strategies for Refractory Social Anxiety Disorder

Publication date: 01 January 2014

Pages44–53

Adding clonazepam increases the likelihood of response in patients with social anxiety disorder who remain symptomatic after a trial with an SSRI, supporting the common clinical practice of combining a benzodiazepine with an SSRI. Among 181 nonresponders ...

https://doi.org/10.1176/appi.ajp.2013.12101353

Short-Term Use of Serotonin Reuptake Inhibitors and Risk of Upper Gastrointestinal Bleeding

Publication date: 01 January 2014

Pages54–61

Short-term SSRI use—even as little as 7 days—elevated the risk of upper gastrointestinal bleeding, especially in male patients. Just as with NSAIDs and aspirin, physicians should carefully monitor for this side effect.

https://doi.org/10.1176/appi.ajp.2013.12111467

Lower Gene Expression for KCNS3 Potassium Channel Subunit in Parvalbumin-Containing Neurons in the Prefrontal Cortex in Schizophrenia

Publication date: 01 January 2014

Pages62–71

Objective In schizophrenia, alterations in markers of cortical GABA neurotransmission are prominent in parvalbumin-containing neurons. Parvalbumin neurons selectively express KCNS3, the gene encoding the Kv9.3 potassium channel α-subunit. Kv9.3 subunits ...

https://doi.org/10.1176/appi.ajp.2013.13040468

A Genome Scan for Loci Shared by Autism Spectrum Disorder and Language Impairment

Publication date: 01 January 2014

Pages72–81

A study of 79 families with one child with autism and at least one child with a language impairment revealed a possible genetic connection between autism in children and language problems in other family members. Genes in a narrow region of two ...

https://doi.org/10.1176/appi.ajp.2013.12081103

The Neural Correlates of Anomalous Habituation to Negative Emotional Pictures in Borderline and Avoidant Personality Disorder Patients

Publication date: 01 January 2014

Pages82–90

Failure to attain emotional habituation may contribute to the rapidly and abruptly shifting moods that characterize borderline personality disorder. The absence of increased dorsal anterior cingulate activity during habituation to negative pictures was ...

https://doi.org/10.1176/appi.ajp.2013.13070852

Neuropsychological Decline in Schizophrenia From the Premorbid to the Postonset Period: Evidence From a Population-Representative Longitudinal Study

Publication date: 01 January 2014

Pages91–101

Objective Despite the widespread belief that neuropsychological decline is a cardinal feature of the progression from the premorbid stage to the chronic form of schizophrenia, few longitudinal studies have examined change in neuropsychological functioning ...

https://doi.org/10.1176/appi.ajp.2013.12111438

Patient Personality and Therapist Response: An Empirical Investigation

Publication date: 01 January 2014

Pages102–108

Objective The aim of this study was to examine the relationship between therapists’ emotional responses and patients’ personality disorders and level of psychological functioning. Method A random national sample of psychiatrists and clinical psychologists (N=...

https://doi.org/10.1176/appi.ajp.2013.13020224

A Randomized Controlled Trial of Psychoanalytic Psychotherapy or Cognitive-Behavioral Therapy for Bulimia Nervosa

Publication date: 01 January 2014

Pages109–116

Two years of psychoanalytic psychotherapy and 5 months of CBT with follow up visits for bulimia nervosa were compared. The proportions of patients who had stopped binging and purging at 2 years were 15% for psychoanalytic psychotherapy and 44% for CBT. ...

https://doi.org/10.1176/appi.ajp.2013.12121511