Neurological and Psychiatric Findings of Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient With High Blood Glucose Levels

A 63-year-old woman was being followed in the internal medicine clinic for unstable high blood glucose levels and the neurology department received a consultation due to the fluctuation in the level of consciousness and agitation. Her medical history included diabetes mellitus, chronic renal failure, and hypertension, with no history of alcohol consumption or smoking. The initial symptoms began 6 days earlier, with severe nausea and vomiting only a few times. Her neurological examination revealed reduction of word expression, impaired memory, and attention with agitation. Brain MRI scans revealed symmetrical and bilateral hyperintense lesions on diffusion-weighted images and T2-weighted images throughout the entire corpus callosum (Figure 1 [A and C]). These areas were hypointense on apparent diffusion coefficient sequences (Figure 1 [B]). No pathological contrast enhancement was detected. Electroencephalography demonstrated active epileptiform discharges in the right frontocentral region extending to the homologous areas of the left hemisphere. Laboratory findings were as follows: blood glucose, 557.49 mg/dL; sodium, 124.39 mmol/L; potassium, 6.11 mmol/L; BUN, 70.5 mg/dL; and creatinine, 3.72 mg/dL (chronic renal failure: mean creatinine 3.2 mg/dL). Plasma osmolarity was 304.9 mOsm/L. Cerebrospinal fluid findings were normal.

The appearance of the observed lesions was compatible with MBD. There was no pathology in the paraneoplastic panel. On the 10th day of follow-up with blood glucose stabilization, correction of metabolic disturbances, and intravenous nutritional support, the patient’s neurological examination revealed marked improvement of memory and attention, with a significant increase in perception. Cranial MRI scans also showed partial normalization. On the 15th day, the patient had an intact neurological examination and was discharged.

MBD is a rare but frequently fatal disease, and is often characterized by corpus callosum demyelination and necrosis.¹ The disease frequently develops after chronic alcohol consumption, but nonalcoholic MBD may also occur, even in patients with metabolic disorders with or without malnutrition.^1,3 The acute form of MBD is characterized by impairment of consciousness, epileptic seizures, and coma.¹ The subacute form may cause mental confusion, psychosis, emotional distress, depression, apathy, and interhemispheric disconnection.^1,4 Progressive dementia dominates the clinical course of the chronic form of the disease.¹ Death often occurs in association with sudden cardiorespiratory failure after necrosis of some parts of the limbic regions.⁵

Yadala and Luo⁶ recently reported a nonalcoholic diabetic case of MBD in a 38-year-old man with a wide range of unstable and fluctuant blood glucose levels. The authors suggested the possibility of energy production disarrangement occurring in the corpus callosum. In our presented case, a history of vomiting a few times caused only mild malnutrition. Therefore, this suggests that long-standing untreated diabetes mellitus and high blood glucose levels as well as related hyperosmolarity may have triggered MBD.

Early recognition and treatment of the disease may provide favorable clinical outcomes.^1,5 However, until now, there have been no reports of a specific proven treatment for MBD. Nutritional support and cessation of alcohol intake are important during treatment.¹

In conclusion, acute onset MBD is not always fatal, and complete recovery is possible after timely diagnosis and appropriate treatment.^1,3,5 In addition, it should be noted that nonalcoholic MBD may occur even in metabolic disorders with or without malnutrition, and advanced neuroimaging techniques such as MRI facilitate early diagnosis of MBD.