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Reviews and Overviews
Published Online: 5 February 2019

Systematic Review of Symptom Assessment Measures for Use in Measurement-Based Care of Bipolar Disorders

Abstract

Objective:

Utilization of measurement-based care (MBC) for bipolar disorders is limited, in part because of uncertainty regarding the utility of available measures. The aim of this study was to synthesize the literature on patient-reported and clinician-observed measures of symptoms of bipolar disorder and the potential use of these measures in MBC.

Methods:

A systematic review of multiple databases (PubMed, Embase, PsycINFO, Cochrane Library, and other gray literature) was conducted in June 2017 to identify validated measures. Data on the psychometric properties of each measure were extracted and used to assess the measure’s clinical utility on the basis of established guidelines.

Results:

Twenty-eight unique measures were identified in 39 studies, including four patient-reported and six clinician-observed measures assessing manic symptoms, three patient-reported and five clinician-observed measures of depressive symptoms, and six patient-reported and four clinician-observed measures of both symptom types. Patient-reported measures with the highest clinical utility included the Altman Self-Rating Mania Scale for assessment of manic symptoms, the Quick Inventory of Depressive Symptomatology–Self Report (QIDS-SR) (depressive symptoms), and the Internal State Scale (both types). Highly rated clinician (C)-observed scales were the Bech-Rafaelsen Mania Rating Scale (mania), the QIDS-C (depressive symptoms), and the Bipolar Inventory of Symptoms Scale (both types).

Conclusions:

Suitable choices are available for MBC of bipolar disorders. The choice of a measure could be informed by clinical utility score and may also depend on how clinicians or practices weigh each category of the clinical utility scale and on the clinical setting and presenting problem.

HIGHLIGHTS

This systematic review assessed the clinical utility of symptom measures for use when treating individuals with bipolar disorder.
Of 28 measures evaluated: 10 assess manic symptoms, eight assess depressive symptoms, and 10 assess both manic and depressive symptoms.
Clinical utility scores were based on each measure’s reliability, validity, and ease of use.
Measures with high clinical utility included the Altman Self-Rating Mania Scale, the Bech-Rafaelsen Mania Rating Scale, the Quick Inventory of Depressive Symptomatology, the Internal State Scale, and the Bipolar Inventory of Symptoms Scale.
Even while engaging in treatment, many individuals with a bipolar disorder experience symptoms of mania and depression that fluctuate or occur concurrently (17). Failure to systematically assess symptoms and compare them with prior clinical status can lead to inaccurate detection of nonresponse and uncertainty about when to make treatment changes (8). Likewise, the presence of residual depressive or hypomanic symptoms is associated with poor outcomes, including recurrence of a mood episode (7)—highlighting the need for ongoing symptom assessment and treatment to target (i.e., remission).
Measurement-based care (MBC) is a clinical strategy involving regular measurement of symptom frequency and severity, side effects, and treatment adherence and use of those findings to inform clinical decision making (911). Existing literature demonstrates that MBC is effective for treating patients with most psychiatric disorders and that adoption of MBC has been recommended in the treatment of individuals with a range of psychiatric illnesses (9).
In the past decade, several organizations have recommended the adoption of MBC specifically for the treatment of bipolar disorder. In 2009, the International Society for Bipolar Disorders (12) recommended using symptom measures at baseline and at follow-up clinical visits to aid clinicians in determining clinical response and remission for individuals with bipolar disorder. The report also noted that symptom measurement can provide additional clinical insights, such as determining the predominant polarity of a mixed episode (12). Guidelines published by the U.S. Department of Veterans Affairs (VA) and the Department of Defense (DoD) also recommend using symptom measures to monitor treatment of bipolar disorder, but unlike VA/DoD guidelines for depression (13), they do not provide specific instructions about which measures to use, how to interpret results of any specific measure, or frequency of measurement (14). The absence of clear guidance in MBC of bipolar disorder—as well as limited clinician understanding of available measures that could be used as options—may have contributed to low adoption of MBC for this clinical population.
Prior reviews of bipolar disorder measures, published in 2009 (15) and 2013 (16), included measures of bipolar disorder symptoms and screening tools and other instruments that are not used for serial symptom assessment. Neither review used a comprehensive systematic review methodology that included searching multiple databases, assessed a full range of psychometric properties, or evaluated clinical utility. We sought to extend prior reports by conducting a systematic review of instruments that could be used for MBC of bipolar disorder. In particular, we sought to answer the following questions, What patient-reported and clinician-observed measures of bipolar disorder symptoms exist? What are the psychometric properties and clinical utility of the existing measures?

Methods

We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method to conduct and report the results of this review (17).

Search Strategy

Search strategies were developed to capture articles about bipolar disorders, symptom measures, and measurement psychometrics. (Complete search strategies are available in the online supplement). Searches were constructed by using a combination of keywords and standardized terms in PubMed, Embase, PsycINFO, and the Cochrane Register of Controlled Trials. Gray literature sources were also searched, including ClinicalTrials.gov, ProQuest Dissertations and Theses, and the World Health Organization’s International Clinical Trials Registry Platform. Results were filtered for English articles, adults, and years 1990 to the present. Searches were conducted in June 2017. Citations were managed in EndNote, including removal of duplicates, and the excluded and included citations were organized by using the Rayyan Web application for systematic reviews. Reference lists of selected studies, including the literature reviews (15, 16), were hand-searched to identify additional scales, including those described in articles published before 1990.

Eligibility and Exclusion

Article titles found in the search were screened for relevance to the topic by the first author. Selected abstracts were then screened. Articles were eligible if they described symptom measures for adults with a bipolar disorder, were published in English, and addressed measurement psychometrics (e.g., validity or reliability).
Studies that did not report on individuals with a bipolar disorder, did not include adult populations, did not measure bipolar disorder symptoms, or did not include primary data (e.g., review articles) were excluded. We also excluded reports on instruments that would not be appropriate for use in MBC, such as screening measures used for case identification and instruments assessing only one symptom (e.g., suicidal ideation).

Data Abstraction

We developed a data abstraction tool. Abstracted information included study author and year; study population and clinical setting; and other details about the measure, including the number of items, time frame assessed, and scoring of items. One author (JMC) reviewed eligible studies to complete the data abstraction tool. All eligible studies were reviewed by two additional authors (SBG and JCF) to assess information required for computing the clinical utility scores described below. Disagreements were resolved through discussion among authors and through consultation with a multidisciplinary group of researchers within the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. Corresponding authors were contacted for missing data.
To quantify the clinical utility of the included measures, we adapted a method developed by Zimmerman et al. to describe the clinical utility of symptom measures (18). Clinical utility was assessed based on 11 items related to content, use, or psychometrics of the measure for individuals with bipolar disorder, including three items of validity and two items of reliability. Items (with cutoff criteria when applicable) included whether the instrument was brief (≤18 items); assessed suicidal thoughts; was easy to score (total score computed by adding individual item responses); was publicly available (determined by author report or identified through Internet search); reported a remission indicator in included study (a score suggesting clinical remission); and was adequate in internal consistency (Cronbach’s α ≥.7), test-retest reliability (Pearson correlation coefficient ≥.6), content validity (proportion of assessed DSM-5 symptoms of depression and mania), concurrent validity (Pearson or Spearman’s correlation coefficient ≥.6), construct validity (either convergent or discriminant validity; p<.05), and sensitivity to change (p<.05). Cutoffs for psychometric properties were based on prior reports (1921).
Reliability items assessed the degree to which an instrument consistently measures a construct, across both items and time points. Internal consistency assessed whether the instrument consistently measures the construct across items in the scale. Test-retest reliability assessed whether the instrument measures the construct consistently across time. Content validity assessed the extent to which the instrument measures all facets of a given construct. Concurrent validity assessed whether the instrument measures the same construct as a validated instrument when administered at the same time. In most cases, construct validity was assessed by whether the scale distinguishes between patients diagnosed as having (convergent validity) or not having (discriminant validity) the relevant diagnosis. Discriminant validity assessed whether the instrument does not measure unrelated constructs. Sensitivity to change assessed whether the instrument captures variation in symptoms over time.
Each item was initially given a score of 0 if the item was absent or did not meet cutoff criterion and a score of 1 if the item was present and met cutoff criterion, with two exceptions. The test-retest reliability item was scored 0.5 if the item was found to meet cutoff criterion only in a control group. The content validity item was given a score from 0 to 1 based on the proportion of DSM symptoms included in the measure, depending on whether the measure was intended to assess depression, mania, or depression and mania. A score of 1 indicated that all DSM-5 symptoms from the relevant category (or categories) are included in the measure, and a score of 0 indicated that no DSM-5 symptoms from the relevant category (or categories) are included (22). For measures that do not include all DSM-5 symptoms, the total number of DSM-5 symptoms included was divided by the number of relevant symptoms listed in DSM-5 for the respective condition (nine for measures assessing only depressive symptoms, seven for measures assessing only manic symptoms, and 16 for measures assessing both). Given that the sample size required to assess a measure’s reliability and validity is partially dependent on the length (i.e., number of items) of the measure (23), scores for psychometric items were adjusted based on the ratio of sample size to number of items in the measure. Ratios of sample size to item were calculated based on the sample size used in the analysis of the measure’s psychometric property. If a measure was evaluated in multiple studies, we added the analytical sample sizes together. The initial score was multiplied by one if the ratio of sample size to item was excellent (≥10), by 0.75 if the ratio was very good (≥5 and <10), by 0.5 if the ratio was good (≥3 and <5), by 0.25 if the ratio was fair (≥2 and <3), and by 0 if the ratio was poor (<2). A clinical utility score ranging from 0 to 11 was determined for each measure by summing the values for each of the 11 components, with higher scores reflecting higher utility.

Results

Our search resulted in 4,617 citations, and 14 citations were identified through other sources such as hand-searching of bibliographies. After the removal of 417 duplicate citations, 4,214 unique citations remained and were assessed through title and abstract review. Seventy-three studies were assessed for eligibility through full-text review, and 39 studies (2462) were included in the qualitative synthesis and clinical utility scoring. Search results are shown in a flow diagram (see figure in online supplement). A summary of included studies is shown in Table 1.
TABLE 1. Results of a systematic review of studies that assessed measures of symptoms of bipolar disorder, by type of symptoms
Measure and studyStudy population and clinical settingN of itemsTime frame of symptoms or findingsResponse formatClinical utility scorea
Manic symptoms (patient-reported)
Self-Report Manic Inventory    4.9
 Shugar et al., 1992 (24)25 hospitalized patients with mania, 82 patients without mania481 month prior to admissionYes/no for each item 
 Bräunig et al., 1996 (25)38 hospitalized patients with mania, 66 patients without mania47Preceding weekYes/no for each item 
 Cooke et al., 1996 (26)155 outpatients with bipolar disorder47Preceding weekYes/no for each item 
Altman Self-Rating Mania Scale    9.6
 Altman et al., 1997 (27)34 hospitalized patients with mania, 71 patients without mania5Preceding weekEach item scored 0 to 4 
Interactive Computer Interview for mania    3
 Reilly-Harrington et al., 2010 (28)100 nonhospitalized individuals with diagnosis of bipolar disorderVariablePreceding weekEach item has five grades of severity 
Computerized Adaptive Testing–Mania    4
 Achtyes et al., 2015 (29)25 outpatients with bipolar disorderAverage of 18 items (from 89-item bank)Preceding 2 weeksEach item scored from –2 to 2 
Manic symptoms (clinician-observed)
Modified Manic State Rating Scale    3
 Blackburn et al., 1977 (30)16 hospitalized patients with current mania28At time of examEach item scored from 0 to 5 
Bech-Rafaelsen Mania Rating Scale    6.55
 Bech et al., 1978 (31)38 hospitalized patients with current mania11At time of examEach item scored from 0 to 4 
 Bech et al., 2001 (32)80 hospitalized patients with mania, goal of assessing rapid effect of antipsychotic medication11At time of examEach item scored from 0 to 4 
Bech-Rafaelsen Mania Rating Scale– Modified100 hospitalized patients with mania10At time of examEach item scored from 0 to 45.6
 Licht and Jensen, 1997 (33)     
Young Mania Rating Scale    4
 Young et al., 1978 (34)20 hospitalized patients with current mania11At time of exam, no indicated duration for retrospective items, such as sleepEach item has 5 grades of severity 
Clinician-Administered Rating Scale for Mania    4
 Altman et al., 1994 (35)14 videotaped hospitalized patients14At time of examEach item scored from 0 to 5 or 0 to 4 
Observer-Rated Scale for Maniab    4.75
 Krüger et al., 2010 (36)113 hospitalized patients with bipolar disorder49 itemsPreceding weekEach item scored true or false 
Depressive symptoms (patient-reported)
Inventory of Depressive Symptomatology–Self-Report (SR)    4
 Rush et al., 2000 (37)141 patients with bipolar disorder from outpatient public-sector settings30Preceding weekEach item scored from 0 to 3 
Carrol Depression Scale    2.8
  Cassidy et al., 2009 (38)94 hospitalized patients with bipolar disorder with current mania or mixed symptoms52At time of examEach item scored yes or no 
Quick Inventory of Depressive Symptomatology–SR    6.75
 Bernstein et al., 2010 (39)141 patients with bipolar disorder from outpatient public-sector settings16Preceding weekEach item scored from 0 to 3 
Depressive symptoms (clinician-observed)
Inventory of Depressive Symptomatology     
 Trivedi et al., 2004 (40)402 outpatients with bipolar disorder from 19 public-sector mental health clinics30Preceding weekEach item scored from 0 to 37
Quick Inventory of Depressive Symptomatology     
 Trivedi et al., 2004 (40)402 outpatients with bipolar disorder from 19 public-sector mental health clinics16Preceding weekEach item scored 0 to 310
 Bernstein et al., 2009 (41)405 outpatients with bipolar disorder from 19 public-sector mental health clinics16Preceding weekEach item scored 0 to 3 
Bipolar Depression Rating Scale    5.5
 Berk et al., 2007 (42)122 patients with bipolar disorder from inpatient, outpatient, private, and public settings24Preceding several daysEach item scored from 0 to 3 
Hamilton Depression Rating Scale (HAMD)     
 Kolodziej et al., 2008 (43)105 outpatients with bipolar disorder and concurrent substance use27Preceding weekEach item scored from 0 to 2, 3, or 46
HAMD-5    8.3
 González-Pinto et al., 2009 (44)173 hospitalized patients or from day hospital with bipolar disorder with current mixed symptoms5Preceding weekNot reported 
Depressive and manic symptoms (patient-reported)
Internal State Scale    7.73
 Bauer et al., 1991 (45)89 patients with bipolar disorder or major depression from academic inpatient and outpatient settings; 24 control group participants17Past 24 hoursEach item scored from 0 to 100 
 Cooke et al., 1996 (26)155 outpatients with bipolar disorder15Preceding weekEach item scored from 0 to 100 
 Bauer et al., 2000 (46)86 outpatients with bipolar disorder at 4 VA clinics15Past 24 hoursEach item scored from 0 to 100 
ChronoRecord    4.2
 Bauer et al., 2004 (47)80 outpatients with bipolar disorder at academic mood disorder specialty clinic6Past 24 hoursMood item scored from 0 to 100 
 Bauer et al., 2008 (48)27 hospitalized patients with current mania6Past 24 hoursMood item scored 0 to 100 
Affective Self-Rating Scale    7.15
 Adler et al., 2008 (49)53 outpatients with bipolar disorder18Preceding weekEach item scored from 0 to 4 
 Adler et al., 2011 (50)231 outpatients with bipolar disorder18Preceding weekEach item scored from 0 to 4 
Multidimensional Assessment of Thymic States    3.5
 Henry et al., 2008 (51)152 outpatients with bipolar disorder, 44 individuals without bipolar disorder20Preceding weekEach item scored from 0 to 10 
 Henry et al., 2013 (52)141 individuals with bipolar disorder (combination of inpatient and outpatient)20Preceding weekEach item scored from 0 to 10 
NIMH Prospective Life Chart Methodology–Self    5.2
 Born et al., 2014 (53)108 outpatients with bipolar disorder2Past 24 hoursMood item scored from –4 to 4 
 Schärer et al., 2015 (54)54 outpatients with bipolar disorder2Past 24 hoursMood item scored from –4 to 4 
Daily Mood Monitoring    1.4
 Schwartz et al., 2016 (55)10 outpatients with bipolar disorder6Past 24 hoursSymptom items scored from 0 to 100. Social stress items scored from 1 to 7 
Depressive and manic symptoms (clinician-observed)
NIMH Prospective Life Chart Methodology–Clinician    7.6
 Denicoff et al., 1997 (56)30 outpatients with bipolar disorder2Over time since last appointmentLikert scale from 0 to 25 
 Denicoff et al., 2000 (57)270 outpatients with bipolar disorder2Over time since last appointmentLikert scale from 0 to 25 
Clinical Monitoring Form    5.65
 Sachs et al., 2002 (58)58 outpatients with bipolar disorder18Over time since last appointmentEach section scored differently; also used as progress note 
Brief Bipolar Disorder Symptom Scale    6.5
 Dennehy et al., 2004 (59)409 outpatients with bipolar disorder treated in 13 mental health clinics10At time of examinationEach item scored from 1 to 7 
Bipolar Inventory of Symptoms Scale    8
 Bowden et al., 2007 (60)20 outpatients with bipolar disorder44Preceding weekEach item scored from 0 to 4 
 Gonzalez et al., 2008 (61)224 outpatients with bipolar disorder44Preceding weekEach item scored from 0 to 4 
 Singh et al., 2013 (62)116 outpatients with bipolar disorder44Preceding weekEach item scored from 0 to 4 
a
Possible scores range from 0 to 11, with higher scores reflecting higher utility. Scores for measures that were evaluated by multiple studies were calculated by determining whether an item was present and met cutoff criteria in any study, and, if so, the measure received 1 point (modified based on the sample size to item ratio for psychometric items).
b
The measure was developed for use by nonprofessionals to facilitate communication with clinicians, although it is also possible for clinicians to use it for comparisons over time.
Twenty-eight symptom measures were identified in 39 studies, including 10 measures of manic symptoms (four patient-reported and six clinician-observed), eight measures of depressive symptoms (three patient-reported and five clinician-observed), and 10 measures of both manic and depressive symptoms (six patient-reported and four clinician-observed). One measure, the Observer-Rated Scale for Mania (36), was developed to help nonclinicians communicate with clinicians, although the measure could be used over time by clinicians to monitor treatment. For this study it was classified as a clinician-observed measure of manic symptoms.

Measures Assessing Manic Symptoms

Thirteen studies (2436) described 10 instruments assessing manic symptoms only. Four instruments were patient-reported, and six were clinician-observed. Seven measures (27, 3036) of manic symptoms, including all six clinician-observed measures, were initially tested among hospitalized patients with bipolar disorder who were receiving treatment for mania. Most clinician-observed measures assessed current symptoms, whereas all patient-reported measures assessed symptoms over the preceding week to month. The number of items per measure ranged from five to 49, with two patient-reported measures (28, 29) having a variable number of items contingent on patient response. Four studies (26, 28, 33, 36) (evaluating three different measures) included at least 100 patients with bipolar disorder.
Overall clinical utility scores and scores for each item are shown in Table 2 (see online supplement for expanded information). For measures of manic symptoms, clinical utility scores ranged from 3 to 9.6 for patient-reported measures and from 3 to 6.55 for clinician-observed measures. The measure with the highest clinical utility score was the patient-reported Altman Self-Rating Mania Scale (27). The clinician-reported measure with the highest clinical utility score, the Bech-Rafaelsen Mania Rating Scale (31, 32), included tests of internal consistency but lacked tests of test-retest reliability and discriminant validity.
TABLE 2. Summary of clinical utility scores for measures of symptoms of bipolar disorder, by item and type of symptoms
  Itema 
MeasureStudyBrief (<18 items)Assesses suicidal thoughtsEasy to scorePublic clinical useRemission indicatorInternal consistency and interrater reliabilitybTest-retest reliabilitycContent validity with DSMdConcurrent validitybConvergent or discriminant validitybSensitivity to changebTotale
Manic symptoms (patient-reported)
Self-Report Manic InventoryShugar et al., 1992 (24); Bräunig et al., 1996 (25); Cooke et al., 1996 (26)00110.5.5.9.25.5.254.9
Altman Self-Rating Mania ScaleAltman et al., 1997, (27)1011111.61119.6
Interactive Computer Interview for Mania–Young Mania Rating ScaleReilly-Harrington et al., 2010 (28)000001011003
Computerized Adaptive Testing–ManiaAchtyes et al., 2015 (29)110010010004
Manic symptoms (clinician-observed)
Modified Manic State Rating ScaleBlackburn et al., 1977 (30)001100010003
Bech-Rafaelsen Mania Rating ScaleBech et al., 1978 (31); Bech et al., 2001 (32)1011110.800.756.55
Bech-Rafaelsen Mania Rating Scale–ModifiedLicht and Jensen, 1997 (33)1011000.61015.6
Young Mania Rating ScaleYoung et al., 1978 (34)101100000004
Clinician-Administered Rating Scale for ManiaAltman et al., 1994 (35)101100010004
Observer-Rated Scale for ManiaKrüger et al., 2010 (36)01110.2501.25.2504.75
Depressive symptoms (patient-reported)
Inventory of Depressive Symptomatology–Self-Report (SR)Rush et al., 2000 (37)011100010004
Carrol Depression ScaleCassidy et al., 2009 (38)0110000.80002.8
Quick Inventory of Depressive Symptomatology–SRBernstein et al., 2010 (39)11110.2501.75.7506.75
Depressive symptoms (clinician-observed)
Inventory of Depressive SymptomatologyTrivedi et al., 2004 (40)011111010107
Quick Inventory of Depressive SymptomatologyTrivedi et al., 2004 (40); Bernstein et al., 2009 (41)1111110111110
Bipolar Depression Rating ScaleBerk et al., 2007 (42)01110.7501.75005.5
Hamilton Depression Rating Scale (HAMD)Kolodziej et al., 2008 (43)10110.5010.506
HAMD-5González-Pinto et al., 2009 (44)1101011.31118.3
Depressive and manic symptoms (patient-reported)
Internal State ScaleCooke et al., 1996 (26); Bauer et al., 1991 (45); Bauer et al., 2000 (46)10011.75.375.61117.73
ChronoRecordBauer et al., 2004 (47); Bauer et al., 2008 (48)1001100.21004.2
Affective Self-Rating ScaleAdler et al., 2008 (49); Adler and Brodin, 2011 (50)1111110.9.25007.15
Multidimensional Assessment of Thymic StatesHenry et al., 2008 (51); Henry et al., 2013 (52)0001010.5.250.753.5
NIMH Prospective Life Chart Methodology–SelfBorn et al., 2014 (53); Schärer et al., 2015 (54)1011100.21005.2
Daily Mood MonitoringSchwartz et al., 2016 (55)1000000.40001.4
Depressive and manic symptoms (clinician-observed)
NIMH Prospective Life Chart Methodology–ClinicianDenicoff et al., 1997 (56);1011110.61017.6
Denicoff et al., 2000 (57)
Clinical Monitoring FormSachs et al., 2002 (58)0111100.9.75005.65
Brief Bipolar Disorder Symptom ScaleDennehy et al., 2004 (59)1010110.51016.5
Bipolar Inventory of Symptoms ScaleBowden et al., 2007 (60); Gonzalez et al., 2008 (61); Singh et al., 2013 (62)01111.75.751.75.7508
a
Each item was given a score of 0 if the item was absent or did not meet the cutoff criterion and a score of 1 if the item was present and met the cutoff criterion.
b
Score was adjusted based on the ratio of sample size to number of items in the measure. Ratios of sample size to item were calculated based on the sample size used in the analysis of the measure’s psychometric property. If a measure was evaluated in multiple studies, we added the analytical sample sizes together. The initial score was multiplied by 1 if the ratio of sample size to item was excellent (≥10), by 0.75 if the ratio was very good (≥5 and <10), by 0.5 if the ratio was good (≥3 and <5), by 0.25 if the ratio was fair (≥2 and <3), and by 0 if the ratio was poor (<2).
c
Test-retest reliability was scored 0.5 if the item was found to meet the cutoff criterion only in a control group.
d
Scored from 0 to 1 based on the proportion of DSM symptoms included in the measure, depending on whether the measure was intended to assess depression, mania, or depression and mania. A score of 1 indicated that all DSM-5 symptoms from the relevant category (or categories) are included in the measure, and a score of 0 indicated that no DSM-5 symptoms from the relevant category (or categories) are included (22). For measures that do not include all DSM-5 symptoms, the total number of DSM-5 symptoms included was divided by the number of relevant symptoms listed in DSM-5 for the respective condition.
e
Possible scores range from 0 to 11, with higher scores reflecting higher utility.
Recent innovations included two studies (28, 29) that evaluated use of computerized technology to improve administration efficiency and clinical accuracy by focusing more specifically on relevant symptom areas. One measure used adaptive testing technology in which a variable number of items from a bank of 89 were selected for administration on the basis of the prior responses of the patient (29). This scale generates a severity score within a fixed range, regardless of how many items are administered.

Measures Assessing Depressive Symptoms

Eight studies (3744) described eight instruments assessing depressive symptoms only. Three measures were tested in samples including hospitalized patients who were diagnosed as having a bipolar disorder and who were experiencing depressive or mixed symptoms (38, 42, 44). The number of items per measure range from five to 52. All five studies (4044) evaluating clinician-observed measures included at least 100 patients with bipolar disorder.
Clinical utility scores for clinician-observed measures ranged from 5.5 to 10. The clinician-observed Quick Inventory of Depressive Symptoms (40, 41) and the five-item Hamilton Depression Rating Scale (HAMD-5) (44) had the highest clinical utility scores (10 and 8.3, respectively). A patient-reported version of the Quick Inventory of Depressive Symptomatology had a relatively high clinical score (6.75).
Five measures (38, 40, 41, 43, 44) were originally developed for use among individuals with major depression before being studied among individuals with bipolar disorder. One measure, the 24-item, clinician-observed Bipolar Depression Rating Scale, was developed specifically for use among individuals diagnosed as having a bipolar disorder on the basis of observed differences in the phenomenology of depression between individuals with bipolar disorder or major depressive disorder (42).

Measures Assessing Both Manic and Depressive Symptoms

Nineteen studies (26, 4562) described 10 instruments assessing both manic and depressive symptoms. Six instruments were patient-reported and four were clinician-observed. The number of items per measure ranges from two to 44. Nine studies included at least 100 individuals with bipolar disorder and evaluated six different measures (26, 5053, 57, 59, 61, 62).
Clinical utility scores ranged from 1.4 to 7.73 for patient-reported measures and from 5.65 to 8 for clinician-observed measures. The instruments with the highest clinical utility scores included the patient-reported Internal State Scale (26, 4548) and the clinician-observed Bipolar Inventory of Symptoms Scale (6062).
Three patient-reported measures (47, 48, 5355), each with up to six items, assess symptoms daily and require individuals with bipolar disorder to complete assessments outside the context of a clinical encounter.

Discussion and Conclusions

This systematic review of measures for assessing symptoms of bipolar disorder identified numerous candidates for use in MBC. Across the 28 measures we identified, approximately half were patient-reported and half were clinician-observed. Ten measures assessed depressive and manic symptoms, whereas the remaining measures assessed either depressive or manic symptoms. On the whole, considerable variability was found regarding the strength of the psychometric properties and clinical utility of the measures reviewed (scores ranged from 1.4 to 10).
Our results also revealed a temporal trend in the type of measures being developed. Measures developed more recently focus on the assessment of depressive symptoms or depressive and manic symptoms among outpatients, whereas earlier studies primarily assessed manic symptoms among hospitalized individuals. This trend is consistent with a growing understanding of the clinical course of patients who experience chronic depressive or mixed symptoms and of the effort to focus more on outpatient care of individuals with bipolar disorder (2, 46, 63).
How might a clinician or practice choose which measure to use? As guidance to clinicians on how to choose among the high number of depression measures, Kroenke (64) recently suggested that measure selection could be informed by clinical utility features—such as ease of scoring, brevity, and degree of uptake by other clinicians. Following this advice, we suggest that the clinical utility scores reported in our study may similarly help to guide clinicians in choosing which measure to use when caring for individuals with bipolar disorder. Choice of a measure may also depend on how each clinician or practice weighs each category of the clinical utility scale (e.g., for some, scale brevity may be more highly valued than test-retest reliability) and on the clinical setting and presenting problem.
This review suggests that a variety of measures have promising clinical utility for use in MBC of bipolar disorder. One patient-reported mania scale, the Altman Self-Rating Mania Scale (27), had a high clinical utility score, with strengths such as being brief and easy to score and having good reliability and validity. Because this measure assesses manic symptoms only, general use in certain settings (e.g., outpatient clinics) would likely require combining it with a depression symptom measure, such as the Quick Inventory of Depressive Symptomatology Self-Report (39). Use of these two patient-reported measures together was described in a report on an MBC program for adults diagnosed as having bipolar disorder (65). Regarding clinician-observed measures, two clinician-observed depression scales, the Quick Inventory of Depressive Symptomatology (40, 41) and the HAMD-5 (44), had high clinical utility scores. However, the clinician-administered mania scales all had lower clinical utility scores than the Altman Self-Rating Mania Scale.
For clinicians and systems that prefer using either the patient-reported method or the clinician-observed method, but not both methods together, the scales assessing both mania and depression may have the most utility. Two patient-reported mania and depression scales—the Internal State Scale (26, 45, 46) and the Affective Self-Rating Scale (49)—had moderately high clinical utility scores (7.73 and 7.15, respectively). The Internal State Scale (26, 45, 46) assesses a range of symptoms consistent with the clinical course of many individuals with bipolar disorder and its psychometric properties have been evaluated in depth, although it is more difficult to score than other measures. The Affective Self-Rating Scale (49) also assesses a range of symptoms, including increased and decreased sleep and thought speed, and is scored by summing item responses, although much of the psychometric evaluation was conducted on a smaller sample size compared with studies of the Internal State Scale.
Two clinician-observed mania and depression scales had moderately high clinical utility scores. The Bipolar Inventory of Symptoms Scale (60), with 44 items and a clinical utility score of 8, has been the focus of a psychometric evaluation in three studies. Clinicians with experience caring for individuals with bipolar disorder or those who work in bipolar disorder specialty settings may be better able to appreciate the detail and subtleties of this measure. The Life Chart Methodology–Clinician, with a score of 7.6, tracks symptoms on a chart, permitting rapid evaluation of an individual’s clinical course over time.
Two studies explored psychiatrist-reported barriers to use of MBC in general (66, 67). Psychiatrists reported not using symptoms measures for reasons including uncertainty about which measure to use. We found that most measures have been examined to some extent for reliability or validity, and numerous measures have moderately high to high clinical utility. In addition, the available patient-reported measures do not require clinician time or expertise in administration and, therefore, address concerns about use of clinician time and the level of familiarity required to administer measures. Given adequate clinic infrastructure, patients could complete the measure before an encounter with a clinician. Furthermore, some measures are intended for patients to complete outside of clinic settings, which may be appropriate if clinic infrastructure cannot support administration of measures. Clinic kiosks or home-based administration can allow patients to complete measures prior to a clinical encounter, allowing results to inform clinical decision making during a subsequent face-to-face visit (64).
The multisite Systematic Treatment Enhancement Program for Bipolar Disorder network of studies included use of the Clinical Monitoring Form, a measure that assesses depressive and manic symptoms, helps clinicians to assess clinical status, and guides decision making at clinic visits (58, 68). Additionally, reports from mood disorder specialty settings and general psychiatry clinics demonstrated the feasibility of using measures to monitor treatment. These reports demonstrated that enhanced treatment programs including symptom measurement for bipolar disorder is associated with better outcomes compared with usual care (6975).
Limitations of the current study included comparing clinical utility scores for measures assessing depressive or manic symptoms only versus measures assessing both symptom domains. Additionally, if a measure lacked testing of a psychometric property, we applied an item score of 0 in the clinical utility score, although it is possible that the property is present and adequate. Although most measures were developed prior to DSM-5, we applied symptoms listed in DSM-5 to assess content validity for all measures, given that this classification reflects current practice. Our database search included results from 1990 to 2017, which includes four years prior to the publication of DSM-IV. It is possible that measures not included in our study were published prior to 1990; however, we identified measures published prior to 1990 through a citation review of included studies and an assessment of two prior reviews of bipolar disorder symptom measures. An expanded literature review of older instruments revealed no additional psychometric testing.
A potential next step could include determining which measures are most acceptable to clinicians and to patients. Additionally, the Patient Health Questionnaire–9 (PHQ-9), a patient-reported measure of depression symptoms in wide use for monitoring treatment of depression, is notably absent from our results because of a lack of studies meeting inclusion criteria. Because the PHQ-9 is commonly used and acceptable to many clinicians, a future direction could be to evaluate the psychometric properties of the PHQ-9, possibly in combination with a measure of manic symptoms, among individuals with bipolar disorder.

Acknowledgments

The authors acknowledge Joan Russo, Ph.D., and Jesse Fann, M.D., M.P.H., for their help with interpreting psychometric properties.

Supplementary Material

File (appi.ps.201800383.ds001.pdf)

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Information & Authors

Information

Published In

Go to Psychiatric Services
Go to Psychiatric Services

Cover: XXXX

Psychiatric Services
Pages: 396 - 408
PubMed: 30717645

History

Received: 16 August 2018
Revision received: 2 November 2018
Accepted: 10 December 2018
Published online: 5 February 2019
Published in print: May 01, 2019

Keywords

  1. bipolar disorder
  2. Scales/outcome & clinical measurement
  3. measurement-based care

Authors

Details

Joseph M. Cerimele, M.D., M.P.H. [email protected]
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Cerimele, Fortney); U.S. Department of Veterans Affairs (VA) Health Services Research & Development (HSR&D) Center of Innovation, Seattle (Fortney); Department of Counseling Psychology, University of Wisconsin–Madison (Goldberg); Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, and Department of Psychiatry, Harvard Medical School, Boston (Miller); M. B. Ketchum Memorial Library, Marshall B. Ketchum University, Fullerton, California (Gabrielson).
Simon B. Goldberg, Ph.D.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Cerimele, Fortney); U.S. Department of Veterans Affairs (VA) Health Services Research & Development (HSR&D) Center of Innovation, Seattle (Fortney); Department of Counseling Psychology, University of Wisconsin–Madison (Goldberg); Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, and Department of Psychiatry, Harvard Medical School, Boston (Miller); M. B. Ketchum Memorial Library, Marshall B. Ketchum University, Fullerton, California (Gabrielson).
Christopher J. Miller, Ph.D.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Cerimele, Fortney); U.S. Department of Veterans Affairs (VA) Health Services Research & Development (HSR&D) Center of Innovation, Seattle (Fortney); Department of Counseling Psychology, University of Wisconsin–Madison (Goldberg); Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, and Department of Psychiatry, Harvard Medical School, Boston (Miller); M. B. Ketchum Memorial Library, Marshall B. Ketchum University, Fullerton, California (Gabrielson).
Stephen W. Gabrielson, M.S.L.I.S.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Cerimele, Fortney); U.S. Department of Veterans Affairs (VA) Health Services Research & Development (HSR&D) Center of Innovation, Seattle (Fortney); Department of Counseling Psychology, University of Wisconsin–Madison (Goldberg); Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, and Department of Psychiatry, Harvard Medical School, Boston (Miller); M. B. Ketchum Memorial Library, Marshall B. Ketchum University, Fullerton, California (Gabrielson).
John C. Fortney, Ph.D.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Cerimele, Fortney); U.S. Department of Veterans Affairs (VA) Health Services Research & Development (HSR&D) Center of Innovation, Seattle (Fortney); Department of Counseling Psychology, University of Wisconsin–Madison (Goldberg); Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, and Department of Psychiatry, Harvard Medical School, Boston (Miller); M. B. Ketchum Memorial Library, Marshall B. Ketchum University, Fullerton, California (Gabrielson).

Notes

Send correspondence to Dr. Cerimele ([email protected]).

Competing Interests

The authors report no financial relationships with commercial interests.

Funding Information

Patient Centered Outcomes Research Institute: PCS-1406-19295
National Center for Advancing Translational Sciences of the National Institutes of Health: UL1 TR002319
VA Office of Academic Affiliations’ Advanced Fellowship in Health Services Research and Development: TPH 61-000-24
Dr. Cerimele was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under award UL1 TR002319 and by a grant (PCS-1406-19295) from the Patient-Centered Outcomes Research Institute (PCORI). Dr. Goldberg was supported by a VA Office of Academic Affiliations’ Advanced Fellowship in HSR&D (TPH 61-000-24). Dr. Fortney was supported by a grant (PCS-1406-19295) from PCORI and by a VA HSR&D Research Career Scientist Award.

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