In Reply

SIR: We read with interest the letter to the editor by Dr. Carroll and colleagues. The authors state that they have “reported 2 cases” with the clinical features of Klüver-Bucy syndrome (KBS), but their reference is to an “unpublished manuscript,” which we unfortunately cannot review. However, we have no quarrel with their argument that KBS may occur when the limbic connections are disrupted outside of the classic anterior temporal area or that patients with these findings may benefit from treatment. Our publication was not designed to address these issues. Instead, we emphasized the ability of magnetic resonance to detect abnormalities in the basolateral amygdala and its cortical connections following chemotherapy in a patient with symptoms similar to KBS. It is our belief that careful neuroimaging combined with clinical testing can unravel this difficult area. We humbly admit that our case illustrates only one aspect of limbic circuitry, and we appreciate the authors' comments.