The Journal of Neuropsychiatry and Clinical Neurosciences

The author reviews the history, accomplishments, and goals of the American Neuropsychiatric Association on the occasion of the tenth anniversary of its founding.

https://doi.org/10.1176/jnp.11.1.8

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The Neurobiology and Pharmacotherapy of Alzheimer's Disease

Publication date: 01 February 1999

Pages19–31

Alzheimer's disease (AD), the most common cause of dementia, has become a major public health concern as our population ages. In recent years, AD has attracted the attention of a wide range of biological disciplines, and substantial progress has been made ...

https://doi.org/10.1176/jnp.11.1.19

Regular Article

Safety and Efficacy of ECT in Patients With Head Injury

Publication date: 01 February 1999

Pages32–37

Electroconvulsive therapy (ECT) is a safe and effective treatment for certain psychiatric disorders. Eleven patients who had sustained a closed head injury were treated with ECT for their psychiatric symptoms. Eight patients responded to an index course ...

https://doi.org/10.1176/jnp.11.1.32

Cognitive and Behavioral Sequelae of Closed Head Injury in Older Adults According to Their Significant Others

Publication date: 01 February 1999

Pages38–44

This study examined the neurobehavioral effects of closed head injury (CHI) in older adults according to their significant others. Informants of 17 mild and moderate CHI patients ≥50 years old when injured completed the Geriatric Evaluation of Relative's ...

https://doi.org/10.1176/jnp.11.1.38

Correlates of Executive Function in Multiple Sclerosis:

Publication date: 01 February 1999

Pages45–50

Proton magnetic resonance spectroscopy (MRS) was performed in a group of patients with multiple sclerosis (MS) and matched control subjects to examine the relationship between frontal lobe pathology and performance on tests of executive function. The N-...

https://doi.org/10.1176/jnp.11.1.45

Neuropsychiatric Manifestations of Multiple Sclerosis

Publication date: 01 February 1999

Pages51–57

The range of neuropsychiatric symptoms in multiple sclerosis (MS) has not been prospectively assessed. The authors, working at a tertiary medical center in Mexico City, used the Neuropsychiatric Inventory (NPI) to evaluate neuropsychiatric symptoms ...

https://doi.org/10.1176/jnp.11.1.51

Neurophysiological Aspects of Synesthetic Experience

Publication date: 01 February 1999

Pages58–65

Synesthesia is a perceptual condition in which stimulation in one sensory modality elicits a concurrent sensation in another. The authors studied possible electrophysiological correlates of synesthetic experience in 17 subjects claiming to continuously ...

https://doi.org/10.1176/jnp.11.1.58

Lack of Effect of Apolipoprotein E E4 Allele on Neuropsychiatric Manifestations in Alzheimer's Disease

Publication date: 01 February 1999

Pages66–70

The association between the apolipoprotein E epsilon 4 (APOE E4) allele and a wide spectrum of behavioral symptoms of Alzheimer's disease (AD) was investigated. Neither the severity nor the presence of any behavioral changes was associated with the number ...

https://doi.org/10.1176/jnp.11.1.66

Reduced Volume of Limbic System–Affiliated Basal Ganglia in Mood Disorders:

Publication date: 01 February 1999

Pages71–78

Volumes of basal ganglia in postmortem brains of 8 patients with mood disorders and 8 control subjects without neuropsychiatric disorder were determined. Morphometry of serial whole-brain sections under the control of postmortem artifacts revealed reduced ...

https://doi.org/10.1176/jnp.11.1.71

Reduction of Motoric Agitation and Restlessness by AF102B and Tacrine in the Macaque

Publication date: 01 February 1999

Pages79–85

The cholinesterase inhibitor tacrine (THA) and the M₁ muscarinic agonist AF102B (cevimeline), both reported to enhance cognition in animals and humans, were tested in 5 macaques for reduction of spontaneous, random movements. Monkeys were videotaped 1 ...

https://doi.org/10.1176/jnp.11.1.79

Clozapine Restores Water Balance in Schizophrenic Patients With Polydipsia-Hyponatremia Syndrome

Publication date: 01 February 1999

Pages86–90

Hyponatremia/hypoosmolemia causes marked morbidity and prolongs hospital stays in a significant subset of schizophrenic patients. Case reports with methodological limitations suggest clozapine ameliorates this water imbalance. To more conclusively assess ...

https://doi.org/10.1176/jnp.11.1.86

Stability of Neurological Soft Signs in Chronically Hospitalized Schizophrenic Patients

Publication date: 01 February 1999

Pages91–96

Neurological soft signs (NSS) have been shown to be more prevalent in chronically ill and in acute or never-medicated patients with schizophrenia. If neurological soft signs are trait-like, then NSS scores should be relatively stable over time and should ...

https://doi.org/10.1176/jnp.11.1.91

Clinical and Research Report

Carbamazepine in the Treatment of Lyme Disease–Induced Hyperacusis

Publication date: 01 February 1999

Pages97–99

Lyme disease–induced hyperacusis can be an intensely disabling, chronic condition that is accompanied by posttraumatic stress disorder–like psychobehavioral sequelae. The authors describe effective treatment of 2 patients with carbamazepine. Speculations ...

https://doi.org/10.1176/jnp.11.1.97

Episodically Remitting Akinetic Mutism Following Subarachnoid Hemorrhage

Publication date: 01 February 1999

Pages100–102

Akinetic mutism is characterized by alertness with near complete absence of volitional activity. The authors report a case of episodically remitting akinetic mutism following subarachnoid hemorrhage.

https://doi.org/10.1176/jnp.11.1.100

Visual Scanning of Facial Expressions in Schizophrenia

Publication date: 01 February 1999

Pages103–106

The authors previously observed that schizophrenic patients generated fewer fixations of ≤50.1 ms in response to faces than did a clinical control group. This study examined whether deficits in short-duration eye movements were related to patients' ...

https://doi.org/10.1176/jnp.11.1.103