Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

https://doi.org/10.1176/jnp.4.2.159

Abstract

Localized cerebral utilization rates for glucose (CMRglu) were determined in 10 detoxified patients with alcoholic organic mental disorders and in 7 age-equivalent normal volunteers using [18F]2-fluoro- 2-deoxyglucose positron emission tomography. Although gray and white matter CMRglu were not significantly different, normalized CMRglu was increased in the left cerebellar and parietal cortical regions and decreased in the right posterior white matter and anterior temporal regions of alcoholic patients, and the pattern of regional CMRglu differed between the two groups. The results suggest functional disruption of right-sided and frontal brain regions and hyperactivity of cerebellar-cortical connections in alcoholic chronic organic mental disorders.

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Published In

The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 4 • Number 2 • May 1992

Pages: 159 - 167

PubMed: 1627977

History

Published in print: May 1992

Published online: 1 April 2006

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Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism

Abstract

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