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Published Online: January 1974

Methyltestosterone with Imipramine in Men: Conversion of Depression to Paranoid Reaction

IAN C. WILSON, ARTHUR J. PRANGE, JR., and PATRICIO P. LARAAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 131, Number 1

https://doi.org/10.1176/ajp.131.1.21

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Abstract

Five men with primary unipolar depression were treated with methyltestosterone and imipramine. Four promptly showed a paranoid response that cleared rapidly when treatment with the hormone was discontinued. The shift from depression to a paranoid reaction may have resulted from an increase in aggression, which may in turn have been the result of the interplay between the hormone and the drug and the effects of this interplay on brain biogenic amine metabolism.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 131 • Number 1 • January 1974

Pages: 21 - 24

PubMed: 4585769

History

Published in print: January 1974

Published online: 1 April 2006

Authors

Affiliations

IAN C. WILSON

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ARTHUR J. PRANGE, JR.

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PATRICIO P. LARA

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Research Psychiatrist, Dorothea Dix Hospital, Raleigh, N.C. 27611

University of North Carolina, Chapel Hill and Professor of Psychiatry and Director of Research Development, Department of Psychiatry and Biological Sciences Research Center

Research Fellow, Department of Psychiatry and University of North Carolina, Chapel Hill

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Methyltestosterone with Imipramine in Men: Conversion of Depression to Paranoid Reaction

Abstract

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