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Research Article
Published Online: February 1976

The dopamine hypothesis of schizophrenia: focus on the dopamine receptor

Publication: American Journal of Psychiatry

Abstract

Alleviation of schizophrenic symptoms by phenothiazines and butyrophenones is associated with blockade of dopamine receptors, while exacerbation of symptoms by amphetamines appears to result from enhanced synaptic activity of dopamine and/or norepinephrine. The author suggests that biochemical labeling of the dopamine receptor with 3H-dopamine and 3H-haloperidol may clarify mechanisms of drug effects on the dopamine receptor.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 197 - 202
PubMed: 1251927

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Published in print: February 1976
Published online: 1 April 2006

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