The UCLA-University of Utah epidemiologic survey of autism: the etiologic role of rare diseases

Publication: American Journal of Psychiatry

https://doi.org/10.1176/ajp.147.12.1614

Abstract

Twelve rare diseases known to cause CNS pathology were found in 26 (11%) of 233 autistic probands identified during a recent epidemiologic survey of Utah. These 26 probands had significantly lower mean IQs than the remaining patients (43 versus 60) but similar sex distribution and prevalence of abnormal EEGs and seizures. The rarity and diversity of these 12 diseases make it highly unlikely that they randomly occurred with autism. Their presence in this epidemiologic survey is the most compelling evidence to date to support the hypothesis that different diseases producing different types of CNS pathology can play an etiologic role in autism.

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Published In

American Journal of Psychiatry

Volume 147 • Number 12 • December 1990

Pages: 1614 - 1621

PubMed: 2244638

History

Published in print: December 1990

Published online: 1 April 2006

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The UCLA-University of Utah epidemiologic survey of autism: the etiologic role of rare diseases

Abstract

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