Characteristics of Depressed Patients Who Report Childhood Sexual Abuse

Our total study group comprised 269 inpatients or outpatients who met DSM-IV criteria for a major depressive episode lasting 24 months or fewer; 171 of the patients were women and 98 were men. All were assessed by one of our mood disorders unit consultants. Full details of the study are provided elsewhere (18). After complete description of the study to the patients, written informed consent was obtained.

Patients completed the Beck Depression Inventory (19) as well as a detailed self-report questionnaire covering sociodemographic variables, previous treatments, and psychiatric family history. Earlier parenting experiences were assessed by using the Parental Bonding Instrument (20) and the Measure of Parental Style (18).

Patients participated in a semistructured interview with a research psychologist followed by a clinical interview with a consultant psychiatrist. The first interview focused on lifetime and current episodes of depression and anxiety disorders (formalized by use of the computerized Composite International Diagnostic Interview [21]). The interview determined a wide range of current and lifetime depressive symptoms, together with histories of drug and alcohol use.

The interviewing psychiatrist assessed clinical features, generated DSM-III-R and DSM-IV depressive diagnoses, completed the 21-item Hamilton depression rating scale (22) and the DSM-III-R Global Assessment of Functioning Scale, rated severity of depression for the current episode on a 0–3-point scale, and asked a set of structured questions about past and present suicidal or self-injurious behaviors.

The interviewing psychiatrist assessed specific characteristics of the patient’s childhood environment in the first 16 years. Using 3-point rating scales (0=no, 1=possibly/likely, 2=definitely), the psychiatrist judged whether the patient had been exposed to a number of early adverse parenting characteristics, including whether the patient had experienced sexual abuse by a parent or by another person before age 16. Patients were assigned to the childhood sexual abuse group if the interviewing psychiatrist rated their exposure to sexual abuse as likely or definite. The inclusion of patients whose exposure was rated as likely was based on literature suggesting a general underestimation bias in reports of childhood sexual abuse (1, 14).

The interviewing psychiatrist judged whether the patient had a substantial personality disturbance preceding the first depressive episode and whether the patient had a long-standing pattern of interpersonal sensitivity resulting in substantial social or occupational impairment. At the end of the interview, the psychiatrist used a 6-point scale (0=not at all to 5=extreme) to rate the extent to which each of 15 personality vignette descriptors matched the patient’s long-term personality style. These descriptors were derived from the 10 DSM-IV personality disorders plus one DSM-IV personality disorder listed for further study (depressive personality disorder), three DSM-III-R personality disorder classes (passive-aggressive, self-defeating, and sadistic), and an anxious personality descriptor (nervy, tense, and a worrier). In addition, the psychiatrist used a 4-point scale (0=no, 1=possibly, 2=probably, 3=definitely) to rate the extent to which the patient’s personality style was disordered across eight parameters defined by Millon (23): inflexible/defective, causing significant personal discomfort, reducing opportunities, inability to function effectively and efficiently, inability to adjust to the environment, vicious or self-defeating cycles, tenuous stability under stress, and personal discomfort to others. The psychiatrist also rated the degree of functionality (1=functional, 2=probably dysfunctional, 3=definitely dysfunctional) across five domains where disordered personality style might be manifested (23): intimate relationships, family relationships, peer relationships, work, and work relationships. Total parameter and domain scores were obtained by summing the eight parameter and five domain scores, respectively.

Forty-six (17%) of the 269 patients reported experiencing childhood sexual abuse before the age of 16 years; 40 (87%) of these 46 patients were women. Because of the preponderance of childhood sexual abuse among women, we elected to study only women; therefore, our study group comprised the 40 women who reported childhood sexual abuse compared with the 131 women who did not report childhood sexual abuse.

The mean ages of the women who did or did not report childhood sexual abuse were 39.1 (SD=13.5, range=19–74) and 44.1 (SD=15.0, range=18–77), respectively (t=1.9, df=169, p=0.06); the trend for a between-group difference in age led us to control for current age in all analyses. The women who did or did not report childhood sexual abuse did not differ significantly on other sociodemographic variables examined, including mean number of years of education, employment, marital status, and whether they were currently involved in an intimate relationship. Of the 40 women who experienced childhood sexual abuse, five (13%) had been abused by a parent only, 28 (70%) had been abused by someone other than a parent, and seven (18%) had been abused by both a parent and someone other than a parent.

Few clinical features distinguished patients with and without a history of childhood sexual abuse. However, patients who reported childhood sexual abuse had made more visits to their psychiatrist in the previous 2 years (mean=26.8, SD=39.0, versus mean=15.1, SD=26.9) (F=4.10, df=1, p=0.04). In addition, more patients who reported childhood sexual abuse admitted to moderate or severe levels of hopelessness at interview (37 [93%] versus 97 [74%]) (χ²=4.90, df=1, p=0.02). The groups were comparable in percentages of self-reported helplessness, sinfulness, guilt, pessimism, worthlessness, and impaired self-image. More patients who were exposed to childhood sexual abuse than patients who were not reported significant feelings of self-annoyance or self-anger (34 [85%] versus 81 [62%]) (χ²=6.04, df=1, p=0.01), and more reported that they could lose control of their anger (19 [48%] versus 34 [26%]) (χ²=5.17, df=1, p=0.02).

There was a difference between groups in severity of depression as measured by self-report Beck depression scores: the patients who had been exposed to childhood sexual abuse had a mean score of 33.7 (SD=9.5), compared with 26.9 (SD=11.4) for those who had not (F=12.65, df=1, p=0.001). There were no significant differences on other depression measures: clinician-rated Hamilton depression scores were 23.8 and 22.0, respectively, for patients who had and had not been exposed to childhood sexual abuse. The consultants’ rating of depression severity yielded similar scores for the two groups (mean=2.25 and mean=2.22, respectively), as did current Global Assessment of Functioning Scale scores (mean=47.2 and mean=50.1, respectively).

No differences in lifetime history measures were observed: patients who reported childhood sexual abuse had had their first episode of major depression at 25.4 years compared with 32.0 years for those with no childhood sexual abuse; the reported number of lifetime episodes of depression were 4.0 and 3.2, respectively; and duration of the current depressive episode was 35.2 and 30.4 weeks, respectively. The two groups of patients had similar rates of nonmelancholic depression according to the criteria of DSM-III-R (22 [55%] and 75 [57%]) and DSM-IV (23 [58%] versus 79 [60%]).

Lifetime prevalence of all anxiety disorders was similar for both groups: 50% of the patients in each group were given a diagnosis of any lifetime anxiety disorder. Social phobia was the most prevalent anxiety disorder for both of the groups: it occurred in 13 (33%) of the patients who had been exposed to childhood sexual abuse and 33 (25%) of those who had not.

Significantly more patients who had been exposed to childhood sexual abuse reported having an alcoholic father than did those who had not (17 [43%] versus 26 [20%]) (χ²=6.77, df=1, p=0.01). No other differences in psychiatric family history were evident.

Table 1 presents the patients’ scores on the Parental Bonding Instrument and the Measure of Parental Style. Patients who had been exposed to childhood sexual abuse had significantly lower care scores for fathers only on the Parental Bonding Instrument. These patients had significantly higher indifference and abuse scores for both parents on the Measure of Parental Style. There were no differences between the groups in Parental Bonding Instrument overprotection scores and Measure of Parental Style overcontrol scores for either parent.

All Measure of Parental Style items were examined individually for group differences (patients who had been exposed to childhood sexual abuse versus those who had not). Items with the four highest odds ratios (i.e., those items from the Measure of Parental Style most strongly associated with childhood sexual abuse) were ranked in descending order for fathers and mothers separately. Items of greatest distinction for fathers identified physical violence, criticism, making the child feel guilty, and making the child feel in danger. For mothers, distinctive items reflected lack of protection and maternal distance (table 2).

Table 3 lists the percentages of patients with and without exposure to childhood sexual abuse who reported certain parental environment characteristics during childhood. Lack of protection against threat posed by others was the most overrepresented experience affirmed by the childhood sexual abuse group. Other overrepresented characteristics were being made to feel unsafe, a dysfunctional father, verbal abuse, and exposure to an unstable relationship between parents. Hence, the general nature of the childhood environment (as measured by the Parental Bonding Instrument, the Measure of Parental Style, and interview-rated parental environment items) was able to distinguish patients with a history of childhood sexual abuse distinctly from those with no childhood sexual abuse.

There were some notable differences in self-injurious behaviors between the two groups (table 4). Significantly more patients who had been exposed to childhood sexual abuse had made a suicide attempt during their current depression, and they had also made more previous suicide attempts. Significantly more patients who had been exposed to childhood sexual abuse had a previous history of self-injury or self-mutilation, and more had been dependent on alcohol in the past. However, current alcohol dependence, past and present benzodiazepine use, and illicit drug use were similar across both groups. These results may have been affected by the fact that we excluded from the study patients with drug- or alcohol-induced depression.

More patients with exposure to childhood sexual abuse than patients with no exposure (26 [65%] versus 42 [32%]) were rated as having evidence of substantial personality disturbance before their current depressive episode (χ²=12.30, df=1, p=0.001). Similarly, patients who had been exposed to childhood sexual abuse were significantly more likely to admit to a long-standing pattern of interpersonal sensitivity (27 [68%] versus 50 [38%]) (χ²=8.80, df=1, p=0.003).

Table 5 examines the differences between the groups on a variety of measures of disordered personality function as well as styles underlying separate personality disorders. Nonsignificant trends were observed for higher domain and parameter dysfunction scores for the patients with a history of childhood sexual abuse. However, the only personality item score that was significantly higher for this group was the borderline descriptor.

Separate logistic regression analyses were used to identify any influence of the borderline personality style variable on the association between childhood sexual abuse and suicidal and self-injurious behaviors. Borderline scores, childhood sexual abuse status, and age (less than 35, 35–50, or more than 50 years) as a categorical covariate were entered into a logistic regression model with current suicide attempt as the dependent variable. The chi-square improvement statistics were 7.20 (df=1, p=0.01) for borderline; 1.37 (df=1, p=0.24) for childhood sexual abuse, and 0.37 (df=1, p=0.83) for age. These results indicate that higher scores on the borderline item were significantly associated with a greater likelihood of there having been a suicide attempt during the current episode. Being in the childhood sexual abuse group did not add further predictive value to the chance of making a current attempt. This analysis was repeated with several suicide attempts (more than five) as the dependent variable. Again the analysis indicated that the borderline descriptor was a dominant predictor of having made more than five previous attempts at suicide (χ²=7.43, df=1, p=0.006) and that the childhood sexual abuse variable (χ²=1.04, df=1, p=0.31) and age (χ²=2.82, df=1, p=0.24) did not add any predictive value beyond that of the borderline descriptor for the existing relationship between childhood sexual abuse and previous suicide attempts.

A further analysis that used previous self-injury as the dependent variable yielded the same result. Borderline scores (χ²=26.37, df=1, p<0.001) rather than childhood sexual abuse status (χ²=0.26, df=1, p=0.69) were associated with the increased likelihood of a history of self-injury.

Thus, the borderline descriptor stood out as a significant mediating influence of self-harmful behaviors in that it appeared to account for the connection between childhood sexual abuse and self-harm. Because of its obvious significance, the borderline variable was examined against other rated parental characteristics. First, all parental environment predictors were correlated with borderline scores to assess whether any overlap existed. Modest but significant relationships were observed between borderline scores and paternal care (r=–0.34, p<0.01), maternal indifference (r=0.40, p<0.01), maternal abuse (r=0.30, p<0.01), paternal indifference (r=0.37, p<0.01), paternal care (r=–0.29, p<0.01), and childhood sexual abuse status (r=0.48, p<0.01). Although some overlap did exist, interpretations concerning the independent role or effect of each predictor variable could not be made because correlation coefficients were not high.

A linear regression analysis examined components of the parental environment (care scores on the Parental Bonding Instrument, indifference and abuse scores on the Measure of Parental Style, childhood sexual abuse status) associated with higher borderline scores. The regression model indicated that having a history of childhood sexual abuse was the only significant variable (t=4.66, df=7, 94, p<0.001) and that the other measures of parental environment were nonpredictive. This result indicates that childhood sexual abuse status contributed to higher borderline scores irrespective of other aberrant characteristics of the parental environment.

Similar analyses were conducted for current suicide attempt, previous attempts, and history of self-injury, with the aim of isolating any independent effects of childhood sexual abuse above and beyond other aberrant parental characteristics on these adult self-harm behaviors. For current suicide attempt, the only characteristic of the early environment that was a significant predictor was childhood sexual abuse status (χ²=4.12, df=1, p=0.04). For several previous suicide attempts, significant predictors were higher maternal indifference scores on the Measure of Parental Style (χ²=4.41, df=1, p=0.03) and having a history of childhood sexual abuse (χ²=4.44, df=1, p=0.03). For history of self-injury, childhood sexual abuse alone and independent of other characteristics had significant predictive value (χ²=4.39, df=1, p=0.03). Thus, for current suicide attempt and history of self-injury, childhood sexual abuse was the dominant predictive characteristic of the early environment, whereas for several previous suicide attempts, high maternal indifference scores and childhood sexual abuse were equally predictive characteristics.