Dr. Kugaya and Colleagues Reply

To the Editor: We agree with the points raised in the letter by Dr. Moses-Kolko et al. To clarify, we applied stringent statistical criteria (statistical parametric mapping voxel threshold of p<0.01) in our study and identified a large and significant increase (>5000 pixels with corrected p=0.001) in the right frontal area of the brain. Differences in sample size or methodology (including statistical parametric mapping statistics) may explain some discrepancies between the studies in affected brain areas.