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Letter to the Editor

Published Online: 1 February 2005

Dr. Hakkarainen and Colleagues Reply

REETA HAKKARAINEN, M.B., TIMO PARTONEN, M.D., JARI HAUKKA, Ph.D., JARMO VIRTAMO, M.D., DEMETRIUS ALBANES, M.D., and JOUKO LÖNNQVIST, M.D., Ph.D.Authors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 162, Number 2

https://doi.org/10.1176/appi.ajp.162.2.402-b

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To the Editor: We appreciate Dr. Astorg’s comments on our article. To answer his first question, we did record the use of fish oil supplements in the cohort. At baseline, 448 (1.5%) of the 29,133 participants reported the use of fish oil supplements. This use was, however, so infrequent that it did not allow for meaningful analysis of its association with the risk of depression.

To address the second comment, we have reported that the trial supplementation had no influence on subsequent self-reported depression or hospital treatment due to major depressive disorder (1). This finding implies that alpha-tocopherol supplementation did not modify the association between the intake of omega-3 fatty acids and the risk of depression.

Our results disagree with some earlier findings about the association of dietary fish with depression. However, we also have cross-sectional data that were assessed at study baseline showing no link between the dietary intake of fish and the self-report of depressed mood (39.3 g/day for both participants with depressed mood and those with no symptoms). Taking these facts together, we still see that our conclusions were justified.

Reference

Partonen T, Haukka J, Virtamo J, Taylor PR, Lönnqvist J: Association of low serum total cholesterol with major depression and suicide. Br J Psychiatry 1999; 175:259–262

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 162 • Number 2 • February 2005

Pages: 402-b - 403

History

Published online: 1 February 2005

Published in print: February 2005

Authors

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REETA HAKKARAINEN, M.B.

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TIMO PARTONEN, M.D.

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JARI HAUKKA, Ph.D.

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JARMO VIRTAMO, M.D.

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DEMETRIUS ALBANES, M.D.

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JOUKO LÖNNQVIST, M.D., Ph.D.

Helsinki, Finland

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Dr. Hakkarainen and Colleagues Reply

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