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Abstract

Objective

Neurocognitive impairments in schizophrenia are well replicated and widely regarded as candidate endophenotypes that may facilitate understanding of schizophrenia genetics and pathophysiology. The Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS) aims to identify genes underlying liability to schizophrenia. The unprecedented size of its study group (N=1,872), made possible through use of a computerized neurocognitive battery, can help further investigation of the genetics of neurocognition. The current analysis evaluated two characteristics not fully addressed in prior research: 1) heritability of neurocognition in African American families and 2) relationship between neurocognition and psychopathology in families of African American probands with schizophrenia or schizoaffective disorder.

Method

Across eight data collection sites, patients with schizophrenia or schizoaffective disorder (N=610), their biological relatives (N=928), and community comparison subjects (N=334) completed a standardized diagnostic evaluation and the computerized neurocognitive battery. Performance accuracy and response time (speed) were measured separately for 10 neurocognitive domains.

Results

The patients with schizophrenia or schizoaffective disorder exhibited less accuracy and speed in most neurocognitive domains than their relatives both with and without other psychiatric disorders, who in turn were more impaired than comparison subjects in most domains. Estimated trait heritability after inclusion of the mean effect of diagnostic status, age, and sex revealed significant heritabilities for most neurocognitive domains, with the highest for accuracy of abstraction/flexibility, verbal memory, face memory, spatial processing, and emotion processing and for speed of attention.

Conclusion

Neurocognitive functions in African American families are heritable and associated with schizophrenia. They show potential for gene-mapping studies.

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Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 459 - 472
PubMed: 20194479

History

Received: 11 September 2008
Accepted: 3 November 2009
Published online: 1 April 2010
Published in print: April 2010

Authors

Details

Monica E. Calkins, Ph.D.
J. Daniel Ragland, Ph.D.
Howard W. Wiener, Ph.D.
Robert M. Savage, Ph.D.
Muktar H. Aliyu, M.D., Dr.P.H.
L. DiAnne Bradford, Ph.D.
Paul D. Lyons, M.D., Ph.D.
Vishwajit L. Nimgaonkar, M.D., Ph.D.
Alberto B. Santos, M.D.
Raquel E. Gur, M.D., Ph.D.

Notes

Presented in part at the 11th International Congress on Schizophrenia Research, Colorado Springs, March 28 to April 2, 2007, and at the 63rd Annual Meeting of the Society of Biological Psychiatry, Washington, D.C., May 1–3, 2008. Received Sept. 11, 2008; revision received Sept. 21, 2009; accepted Nov. 3, 2009. From the Department of Psychiatry, University of Pennsylvania; the Department of Epidemiology, the Department of Psychiatry, and the Department of Human Genetics, University of Pittsburgh; the Department of Psychiatry and Behavioral Sciences, University of California at Davis, Sacramento; the Department of Epidemiology and International Health and the Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham; the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, and the Department of Research, Durham VA Medical Center, Durham, N.C.; the Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson; the Department of Preventive Medicine, Institute for Global Health, Vanderbilt University, Nashville, Tenn.; the Department of Psychiatry, Morehouse School of Medicine, Atlanta; the Department of Psychiatry, University of Tennessee College of Medicine, Memphis; the Department of Neurology, University of Virginia, Charlottesville; the Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston; and the Philadelphia VA Medical Center. Address correspondence and reprint requests to Dr. Calkins, Schizophrenia Research Center and Brain Behavior Laboratory, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, 9 Maloney, 3600 Spruce St., Philadelphia, PA 19104; [email protected] (e-mail).

Funding Information

Dr. Ruben Gur receives grant support through collaborations of the University of Pennsylvania with AstraZeneca, Pfizer, and Merck and may receive royalties from future commercial use of the Penn Computerized Neurocognitive Battery. Dr. Ragland may receive royalties from future commercial use of the Penn Computerized Neurocognitive Battery. Ms. Richard may receive royalties from future commercial use of Penn Computerized Neurocognitive Battery. Dr. Nimgaonkar received a research grant from Lundbeck on an unrelated topic when this article was in preparation. Dr. Raquel Gur receives grant support through collaborations of the University of Pennsylvania with AstraZeneca and Pfizer and may receive royalties from future commercial use of the Penn Computerized Neurocognitive Battery. The remaining authors report no financial relationships with commercial interests.
Supported by NIMH RO1 grants MH-66006, MH-66278, MH-066049, MH-66181, MH-66121, MH-066005, MH-66050, MH-66263, and MH-66004 and NIMH grant K08-MH-79364.

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